来自中国软珊瑚柔指软珊瑚的西努拉弗莱西奥内酯A - K，一种cembrane型二萜类化合物。

Sinulaflexiolides A-K, cembrane-type diterpenoids from the chinese soft coral Sinularia flexibilis.

作者信息

Wen Ting, Ding Yi, Deng Zhiwei, van Ofwegen Leen, Proksch Peter, Lin Wenhan

机构信息

State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China.

出版信息

J Nat Prod. 2008 Jul;71(7):1133-40. doi: 10.1021/np070640g. Epub 2008 Jun 14.

DOI:10.1021/np070640g

PMID:18553926

Abstract

A bioassay-guided fractionation and chemical examination of the soft coral Sinularia flexibilis resulted in the isolation and characterization of sinulaflexiolides A-K (1-11), along with sinulariolone (12), 5-dehydrosinularolide (13), capillolide (14), sinulariolide (15), 5,8-epoxy-9-acetoxysinulariolide (16), flexibilide (17), dihydroflexibilide (18), and the enantiomer of 14-deoxycrassin (19). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 2D NMR) data analysis and by comparison with spectroscopic data reported in the literature. Sinulaflexiolides D and E showed selective inhibitory activity against the gastric gland carcinoma cell line BGC-823 at 8.5 and 0.12 microM, respectively.

摘要

对软珊瑚柔细指软珊瑚进行生物测定指导的分级分离和化学研究，结果分离并鉴定了柔细指软珊瑚内酯A - K（1 - 11），以及指软珊瑚酮（12）、5 - 脱氢指软珊瑚内酯（13）、毛细管内酯（14）、指软珊瑚内酯（15）、5,8 - 环氧 - 9 - 乙酰氧基指软珊瑚内酯（16）、柔细内酯（17）、二氢柔细内酯（18）和14 - 脱氧粗珊瑚内酯的对映体（19）。它们的结构是基于广泛的光谱（红外、质谱、二维核磁共振）数据分析并与文献报道的光谱数据进行比较而确定的。柔细指软珊瑚内酯D和E分别在8.5和0.12微摩尔浓度下对胃腺癌细胞系BGC - 823表现出选择性抑制活性。