来自厚叶肉芝软珊瑚的具有反式稠合内酯的西松烷型二萜类化合物A - F

Crassolides A-F, cembranoids with a trans-fused lactone from the soft coral Sarcophyton crassocaule.

作者信息

Huang Ho-Cheng, Ahmed Atallah F, Su Jui-Hsin, Chao Chih-Hua, Wu Yang-Chang, Chiang Michael Y, Sheu Jyh-Horng

机构信息

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China.

出版信息

J Nat Prod. 2006 Nov;69(11):1554-9. doi: 10.1021/np060182w.

DOI:10.1021/np060182w

PMID:17125220

Abstract

Six new polyoxygenated cembrane-based diterpenoids possessing a trans-fused alpha-methylene-gamma-lactone, crassocolides A-F (1-6), have been isolated along with the known compound 7 from the ethyl acetate extract of a Taiwanese soft coral, Sarcophyton crassocaule. The structures of 1-6 have been established by detailed spectroscopic analysis, including 2D NMR (1H-1H COSY, HMQC, HMBC, and NOESY) spectroscopy, while their absolute configurations were determined using a modified Mosher's method for 1. The structure of 5 was further proven by X-ray diffraction analysis. The full assignment of NMR data of 7 is reported herein for the first time. The cytotoxicity of crassocolides 1-4, 6, and 7 against a limited panel of cancer cells was also determined.

摘要

从台湾软珊瑚厚肉珊瑚（Sarcophyton crassocaule）的乙酸乙酯提取物中，分离出六种新的具有反式稠合α-亚甲基-γ-内酯的多氧化基于cembrane的二萜类化合物，厚肉珊瑚素A-F（1-6），以及已知化合物7。通过详细的光谱分析，包括二维核磁共振（1H-1H COSY、HMQC、HMBC和NOESY）光谱，确定了1-6的结构，而使用改进的莫舍尔方法确定了化合物1的绝对构型。化合物5的结构通过X射线衍射分析进一步得到证实。本文首次报道了化合物7的核磁共振数据的完整归属。还测定了厚肉珊瑚素1-4、6和7对一组有限癌细胞的细胞毒性。