Department of Food and Drug, University of Parma, Parco Area delle Scienze 17/A, 43124, Parma, Italy.
Department of Food and Drug, University of Parma, Parco Area delle Scienze 17/A, 43124, Parma, Italy.
Food Chem Toxicol. 2024 Jun;188:114699. doi: 10.1016/j.fct.2024.114699. Epub 2024 Apr 30.
The aim of this study was to assess Italian consumers' risk of cancer and burden of disease due to dietary exposure to acrylamide. Our model considered six age groups such as infants, toddlers, other children, adolescents, adults, and the elderly, and the consumption of 31 food items. Using a risk-assessment-based approach, we first characterized the risk of neoplastic effects using the margin of exposure method. Then the risk of kidney, endometrial, breast, ovarian cancer, and total cancer was estimated using adjusted cancer slope factors while the burden of disease was quantified using Disability-adjusted Life Years (DALYs). The highest risk for females was related to breast cancer while the lowest was for kidney cancer. We found a comparable risk of total cancer among Italian males and females, estimated at around 1.59 to 3.57 cases per 100,000 individuals annually with the burden ranging between 12.3 - 25.4 and 11.4 - 24.1 DALYs respectively. Our findings provide insights on the multifaceted impact of acrylamide on public health by offering detailed insights into age-specific exposure levels, diverse cancer risks, and the dietary burden of disease related to acrylamide. Targeted interventions and policies can be developed towards mitigating the health risks associated with acrylamide exposure.
本研究旨在评估意大利消费者因饮食摄入丙烯酰胺而致癌的风险和疾病负担。我们的模型考虑了六个年龄组，如婴儿、幼儿、其他儿童、青少年、成年人和老年人，以及 31 种食品的消费。我们采用基于风险评估的方法，首先使用暴露边际法来描述肿瘤效应的风险。然后，使用调整后的癌症斜率因子来估计肾脏、子宫内膜、乳房、卵巢癌和总癌症的风险，同时使用残疾调整生命年（DALY）来量化疾病负担。女性的最高风险与乳腺癌有关，而最低风险与肾癌有关。我们发现意大利男性和女性的总癌症风险相当，估计每年每 10 万人中有 1.59 至 3.57 例，疾病负担分别为 12.3-25.4 和 11.4-24.1 DALY。我们的研究结果提供了关于丙烯酰胺对公共健康的多方面影响的见解，详细介绍了特定年龄组的暴露水平、不同的癌症风险以及与丙烯酰胺相关的疾病饮食负担。可以制定有针对性的干预和政策，以减轻与丙烯酰胺暴露相关的健康风险。
