耐甲氧西林和庆大霉素的金黄色葡萄球菌：对磷霉素、头孢孟多、N-甲酰亚胺硫霉素、克林霉素、夫西地酸和万古霉素的敏感性
Methicillin- and gentamicin-resistant Staphylococcus aureus: susceptibility to fosfomycin, cefamandole, N-formimidoyl-thienamycin, clindamycin, fusidic acid and vancomycin.
作者信息
Graninger W, Leitha T, Breyer S, Francesconi M, Lenz K, Georgopoulos A
出版信息
Drugs Exp Clin Res. 1985;11(1):23-7.
The in vitro activity of fosfomycin against 90 strains of methicillin- and gentamicin-resistant Staphylococcus aureus was studied in an in vitro microtitre system using Mueller-Hinton broth supplemented with glucose-6-phosphate. In parallel the antistaphylococcal activity of cefamandole, N-formimidoyl-thienamycin, clindamycin, fusidic acid and vancomycin was determined with the same organisms. The following MIC50 (MIC95) values were obtained: fosfomycin 8 (128) mg/l, cefamandole 8 (greater than 64) mg/l, clindamycin 0.25 (16) mg/l, fusidic acid less than 0.25 (less than 0.25) mg/l, vancomycin 1 (2) mg/l and N-formimidoyl-thienamycin 4 (16) mg/l. A high MIC/MBC ratio was noted for cefamandole, in contrast to fosfomycin.
在补充了6-磷酸葡萄糖的Mueller-Hinton肉汤的体外微量滴定系统中，研究了磷霉素对90株耐甲氧西林和庆大霉素的金黄色葡萄球菌的体外活性。同时，用相同的菌株测定了头孢孟多、N-甲酰亚胺硫霉素、克林霉素、夫西地酸和万古霉素的抗葡萄球菌活性。获得了以下MIC50（MIC95）值：磷霉素8（128）mg/l，头孢孟多8（大于64）mg/l，克林霉素0.25（16）mg/l，夫西地酸小于0.25（小于0.25）mg/l，万古霉素1（2）mg/l，N-甲酰亚胺硫霉素4（16）mg/l。与磷霉素相比，头孢孟多的MIC/MBC比值较高。
Zotero 插件