替考拉宁、夫西地酸、氟氯西林、磷霉素和万古霉素对耐甲氧西林金黄色葡萄球菌的体外活性。
In vitro activities of teichomycin, fusidic acid, flucloxacillin, fosfomycin, and vancomycin against methicillin-resistant Staphylococcus aureus.
作者信息
Guenthner S H, Wenzel R P
出版信息
Antimicrob Agents Chemother. 1984 Aug;26(2):268-9. doi: 10.1128/AAC.26.2.268.
Abstract
Flucloxacillin, fosfomycin, fusidic acid, teichomycin, and vancomycin were tested against 50 clinical isolates of methicillin-resistant Staphylococcus aureus by a broth macrodilution technique. Teichomycin had a narrow range of activity, similar to that of vancomycin (0.5 to 2.0 micrograms/ml). Fusidic acid had the lowest range of inhibitory activity, with 50 and 90% MICs of 0.19 and 0.35 micrograms/ml, respectively. Flucloxacillin and fosfomycin showed less activity, with MICs up to 32 micrograms/ml.
摘要
采用肉汤稀释法对50株耐甲氧西林金黄色葡萄球菌临床分离株进行了氟氯西林、磷霉素、夫西地酸、替考拉宁和万古霉素的测试。替考拉宁的活性范围较窄，与万古霉素相似（0.5至2.0微克/毫升）。夫西地酸的抑菌活性范围最低，50%和90%的最低抑菌浓度（MIC）分别为0.19和0.35微克/毫升。氟氯西林和磷霉素的活性较低，MIC高达32微克/毫升。
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