CGP 31608、萘夫西林、头孢孟多、亚胺培南和万古霉素对甲氧西林敏感和耐甲氧西林葡萄球菌的比较活性。
Comparative activity of CGP 31608, nafcillin, cefamandole, imipenem, and vancomycin against methicillin-susceptible and methicillin-resistant staphylococci.
作者信息
Sachdeva M, Hackbarth C, Stella F B, Chambers H F
机构信息
Medical Service, San Francisco General Hospital, California 94110.
出版信息
Antimicrob Agents Chemother. 1987 Oct;31(10):1549-52. doi: 10.1128/AAC.31.10.1549.
The activity of CGP 31608 for 53 strains of Staphylococcus aureus and 48 strains of S. epidermidis, both methicillin susceptible and resistant, was compared with that of vancomycin, nafcillin, cefamandole, and imipenem. Microdilution MICs were determined in Mueller-Hinton broth with or without 2.5% NaCl at an inoculum of 3 x 10(5) CFU/ml with a 20-h, 37 degrees C incubation. The MICs of imipenem and CGP 31608 for methicillin-resistant strains were lower than the MICs of nafcillin or cefamandole for these strains; these differences diminished in the presence of 2.5% NaCl. Subpopulations were detected in strains of methicillin-resistant S. aureus and S. epidermidis that were resistant to all the beta-lactam antibiotics tested at 5 micrograms/ml. This resistant subpopulation produced progeny that were uniformly resistant to high concentrations of each of the beta-lactams.
将CGP 31608对53株金黄色葡萄球菌和48株表皮葡萄球菌（包括甲氧西林敏感和耐药菌株）的活性与万古霉素、萘夫西林、头孢孟多和亚胺培南进行了比较。在添加或不添加2.5%氯化钠的Mueller-Hinton肉汤中，以3×10⁵CFU/ml的接种量，在37℃孵育20小时后，通过微量稀释法测定最低抑菌浓度（MIC）。亚胺培南和CGP 31608对耐甲氧西林菌株的MIC低于萘夫西林或头孢孟多对这些菌株的MIC；在存在2.5%氯化钠的情况下，这些差异减小。在耐甲氧西林金黄色葡萄球菌和表皮葡萄球菌菌株中检测到亚群，这些亚群对测试的所有β-内酰胺抗生素在5微克/毫升时均耐药。这种耐药亚群产生的后代对高浓度的每种β-内酰胺类药物均表现出一致的耐药性。
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