Drugeon H B, Caillon J, Juvin M E
CERMIA, Menton, France.
J Antimicrob Chemother. 1994 Dec;34(6):899-907. doi: 10.1093/jac/34.6.899.
The activity of fusidic acid alone and in combination with gentamicin, oxacillin, rifampicin, fosfomycin and ciprofloxacin was investigated against 36 strains of Staphylococcus aureus. The fusidic acid MIC50 of 0.06 mg/L and MIC90 of 0.125 mg/L were determined for 36 strains. Bactericidal activity of fusidic acid was confirmed. Several types of interaction were observed with other antibiotics: dominant effect of fusidic acid over gentamicin; synergy with rifampicin for three or four strains; indifference or dominance with oxacillin, indifference with vancomycin, indifference or dominance with fosfomycin, and indifference with ciprofloxacin. Antagonism was seen with only one strain, following exposure to fusidic acid and rifampicin.
研究了夫西地酸单独以及与庆大霉素、苯唑西林、利福平、磷霉素和环丙沙星联合使用时对36株金黄色葡萄球菌的活性。测定了36株菌的夫西地酸MIC50为0.06mg/L，MIC90为0.125mg/L。证实了夫西地酸的杀菌活性。观察到与其他抗生素有几种相互作用类型：夫西地酸对庆大霉素的主导作用；与利福平对三或四株菌有协同作用；与苯唑西林无相互作用或夫西地酸占主导；与万古霉素无相互作用；与磷霉素无相互作用或夫西地酸占主导；与环丙沙星无相互作用。仅在一株菌中观察到夫西地酸和利福平联合使用时有拮抗作用。
