Synthesis, conformational analysis and antimicrobial activity of 10-benzyl-1,2,4-triazolo[4,3-]1,2,4-triazino[5,6-]indole acyclo -nucleoside analogs.

Condensation of 5-benzyl-3-hydrazino-1,2,4-triazino[5,6-]indole with various sugar aldoses or ketoses gave the corresponding sugar hydrazones as single geometrical isomer or exist in tautomeric isomers. The hydrazones underwent heterocyclization with Fe(Ш)Cl to give the -adduct acyclo -nucleosides: 3-(alditol-1yl)-10-benzyl-1,2,4-triazolo[4,3-]1,2,4-triazino[5,6-]indoles rather than the -adduct: 10-(alditol-1-yl)-3-benzyl-1,2,4-triazolo[3,4-]1,2,4-triazino[5,6-] indoles on the basis of chemical and UV spectral proofs. Conformational analysis of their polyacetates were studied. The new acyclo -nucleosides were evaluated for antimicrobial activity.