Niwetmarin Worawat, Saesian Naiyana, Saruengkhanphasit Rungroj, Eurtivong Chatchakorn, Thasana Nopporn, Ruchirawat Somsak
Program in Chemical Sciences, Chulabhorn Graduate Institute, Bangkok 10210, Thailand.
Center of Excellence on Environmental Health and Toxicology (EHT), OPS, MHESI, Thailand.
Org Biomol Chem. 2024 Jul 24;22(29):5924-5929. doi: 10.1039/d4ob00630e.
A transition-metal- and photocatalyst-free photochemical reaction was successfully developed for the direct acylation of quinoxalin-2(1)-ones, which was enabled by the formation of electron donor-acceptor (EDA) complexes. The use of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as the electron donor allows efficient and operationally simple access to a series of C3-aroylated and acylated quinoxalin-2(1)-ones with moderate to good yields.
通过电子给体-受体（EDA）配合物的形成，成功开发了一种无过渡金属和光催化剂的光化学反应，用于喹喔啉-2(1)-酮的直接酰化反应。使用1,8-二氮杂双环[5.4.0]十一碳-7-烯（DBU）作为电子给体，可以高效且操作简单地获得一系列C3-芳酰化和酰化的喹喔啉-2(1)-酮，产率中等至良好。
