分子上的实验室与多分析物传感
Lab-on-a-molecule and multi-analyte sensing.
作者信息
Magri David C
机构信息
Laboratory of Molecular Logic Gates, Department of Chemistry, Faculty of Science, University of Malta, Msida, Malta.
出版信息
Front Chem. 2024 Apr 18;12:1393308. doi: 10.3389/fchem.2024.1393308. eCollection 2024.
Abstract
The concept of a lab-on-a-molecule, which was proposed just short of two decades ago, has captured the imagination of scientists. From originally being proposed as an AND logic gate driven by three chemical inputs as a direct way of detecting congregations of chemical species, the definition of what constitutes a lab-on-a-molecule has broadened over the years. In this review, molecules that can detect multiple analytes by fluorescence, among other techniques, are reviewed and discussed, in the context of molecular logic and multi-analyte sensing. The review highlights challenges and suggestions for moving the frontiers of research in this field to the next dimension.
摘要
大约20年前提出的“分子上的实验室”概念激发了科学家们的想象力。最初它被提议作为一种由三种化学输入驱动的“与”逻辑门，作为检测化学物种聚集的直接方法，多年来，“分子上的实验室”的定义已经扩大。在这篇综述中，在分子逻辑和多分析物传感的背景下，对能够通过荧光及其他技术检测多种分析物的分子进行了综述和讨论。该综述强调了将该领域的研究前沿推进到新维度所面临的挑战和建议。
相似文献
1
Lab-on-a-molecule and multi-analyte sensing.分子上的实验室与多分析物传感
Front Chem. 2024 Apr 18;12:1393308. doi: 10.3389/fchem.2024.1393308. eCollection 2024.
2
Communicating chemical congregation: a molecular AND logic gate with three chemical inputs as a "lab-on-a-molecule" prototype.传递化学聚集：一种具有三个化学输入的分子“与”逻辑门作为“分子实验室”原型。
J Am Chem Soc. 2006 Apr 19;128(15):4950-1. doi: 10.1021/ja058295+.
3
"AND" luminescent "reactive" molecular logic gates: a gateway to multi-analyte bioimaging and biosensing.“与”发光“反应性”分子逻辑门：通往多分析物生物成像和生物传感的途径。
Org Biomol Chem. 2015 Feb 7;13(5):1294-306. doi: 10.1039/c4ob02076f.
4
Synthesis of a single 1,8-naphthalimide fluorophore as a molecular logic lab for simultaneously detecting of Fe, Hg and Cu.合成一种单一的1,8-萘二甲酰亚胺荧光团作为用于同时检测铁、汞和铜的分子逻辑实验室。
Spectrochim Acta A Mol Biomol Spectrosc. 2018 May 5;196:76-82. doi: 10.1016/j.saa.2018.02.005. Epub 2018 Feb 5.
5
A chemosensor showing discriminating fluorescent response for highly selective and nanomolar detection of Cu²⁺ and Zn²⁺ and its application in molecular logic gate.一种化学传感器，对 Cu²⁺ 和 Zn²⁺具有高选择性和纳摩尔检测的荧光响应，并将其应用于分子逻辑门。
Anal Chim Acta. 2015 May 4;872:63-9. doi: 10.1016/j.aca.2015.02.051. Epub 2015 Feb 20.
6
A hydrophilic naphthalimide-based fluorescence chemosensor forCu ion: Sensing properties, cell imaging and molecular logic behavior.一种基于亲水萘酰亚胺的荧光化学传感器用于 Cu 离子：传感性能、细胞成像和分子逻辑行为。
Spectrochim Acta A Mol Biomol Spectrosc. 2020 Apr 5;230:118029. doi: 10.1016/j.saa.2020.118029. Epub 2020 Jan 7.
7
Selenium- and tellurium-containing fluorescent molecular probes for the detection of biologically important analytes.含硒和碲的荧光分子探针用于检测生物重要分析物。
Acc Chem Res. 2014 Oct 21;47(10):2985-98. doi: 10.1021/ar500187v. Epub 2014 Sep 23.
8
Performance of nano-assembly logic gates with a DNA multi-hairpin motif.具有 DNA 多发夹基序的纳米组装逻辑门的性能。
Nanoscale. 2017 Jan 26;9(4):1709-1720. doi: 10.1039/c6nr07814a.
9
Surface-confined assemblies and polymers for molecular logic.用于分子逻辑的表面受限组装体和聚合物。
Acc Chem Res. 2011 Aug 16;44(8):563-73. doi: 10.1021/ar200002v. Epub 2011 Jun 16.
10
Nucleic acid driven DNA machineries synthesizing Mg2+-dependent DNAzymes: an interplay between DNA sensing and logic-gate operations.核酸驱动的 DNA 机器合成依赖 Mg2+ 的 DNA 酶：DNA 传感与逻辑门操作的相互作用。
Chemistry. 2012 Nov 12;18(46):14689-94. doi: 10.1002/chem.201201995. Epub 2012 Sep 27.
引用本文的文献
1
Naphthalimide-organometallic hybrids as multi-targeted anticancer and luminescent cellular imaging agents.萘酰亚胺-有机金属杂化物作为多靶点抗癌及发光细胞成像剂
RSC Med Chem. 2025 Aug 8. doi: 10.1039/d5md00205b.
本文引用的文献
1
alkaloids - acid, anion-driven fluorescent INHIBIT logic gates with a receptor-fluorophore-spacer-receptor format and PET and ICT mechanisms.生物碱——具有受体-荧光团-间隔基-受体形式以及正电子发射断层扫描（PET）和分子内电荷转移（ICT）机制的酸、阴离子驱动的荧光抑制逻辑门。
RSC Adv. 2023 May 2;13(20):13505-13510. doi: 10.1039/d3ra02704j.
2
Multicomponent synthesis of chromophores - The one-pot approach to functional π-systems.发色团的多组分合成——功能性π体系的一锅法
Front Chem. 2023 Mar 17;11:1124209. doi: 10.3389/fchem.2023.1124209. eCollection 2023.
3
Natural-product-based fluorescent probes: recent advances and applications.基于天然产物的荧光探针：最新进展与应用
RSC Med Chem. 2022 Dec 20;14(3):412-432. doi: 10.1039/d2md00376g. eCollection 2023 Mar 22.
4
A white light emitting reconfigurable pyrazoline-naphthalimide logic gate with magnesium, sodium and proton inputs.一种具有镁、钠和质子输入的白色发光可重构吡唑啉-萘二甲酰亚胺逻辑门。
Chem Commun (Camb). 2023 Apr 11;59(30):4459-4462. doi: 10.1039/d2cc06049c.
5
A unique triple-channel fluorescent probe for discriminative detection of cyanide, hydrazine, and hypochlorite.一种独特的三通道荧光探针，用于选择性检测氰化物、肼和次氯酸盐。
Talanta. 2023 May 15;257:124365. doi: 10.1016/j.talanta.2023.124365. Epub 2023 Feb 16.
6
Converting pH probes into "turn-on" fluorescent receptors for anions.将pH探针转变为用于阴离子的“开启型”荧光受体。
Chem Commun (Camb). 2023 Feb 9;59(13):1717-1727. doi: 10.1039/d2cc06194e.
7
A Tool, an App and a Field: Fluorescent PET Sensors, Blood Electrolyte Analysis and Molecular Logic as Products of Supramolecular Photoscience from Northern Ireland and Sri Lanka.一种工具、一款应用程序与一个领域：荧光正电子发射断层扫描传感器、血液电解质分析以及分子逻辑——作为北爱尔兰和斯里兰卡超分子光科学的产物
Chempluschem. 2023 Apr;88(4):e202200362. doi: 10.1002/cplu.202200362. Epub 2022 Dec 1.
8
Fluorescent contact lens for continuous non-invasive measurements of sodium and chloride ion concentrations in tears.用于连续非侵入性测量泪液中钠离子和氯离子浓度的荧光接触镜。
Anal Biochem. 2020 Nov 1;608:113902. doi: 10.1016/j.ab.2020.113902. Epub 2020 Aug 12.
9
Fluorescent molecular logic gates based on photoinduced electron transfer (PET) driven by a combination of atomic and biomolecular inputs.基于原子和生物分子输入组合驱动的光诱导电子转移 (PET) 的荧光分子逻辑门。
Chem Commun (Camb). 2020 Jun 23;56(50):6838-6841. doi: 10.1039/d0cc00478b.
10
A lab-on-a-molecule with an enhanced fluorescent readout on detection of three chemical species.一种分子水平的实验室，在检测三种化学物质时具有增强的荧光读数。
Chem Commun (Camb). 2019 Apr 23;55(34):4961-4964. doi: 10.1039/c9cc00924h.
Zotero 插件