Yin Chang-Shik, Minh Nguyen Trang Thi, Yi Eun-Ji, Zheng Shengdao, Bellere Arce Defeo, Zheng Qiwen, Jin Xiangji, Kim Myeongju, Park Sejic, Oh Sarang, Yi Tae-Hoo
Acupuncture and Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea.
Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin, Republic of Korea.
Heliyon. 2024 Apr 16;10(9):e29539. doi: 10.1016/j.heliyon.2024.e29539. eCollection 2024 May 15.
Probiotics are intellectually rewarding for the discovery of their potential as a source of functional food. Investigating the economic and beauty sector dynamics, this study conducted a comprehensive review of scholarly articles to evaluate the capacity of probiotics to promote hair growth and manage dandruff.
We used the PRISMA 2020 with Embase, Pubmed, ClinicalTrials.gov, Scopus, and ICTRP databases to investigate studies till May 2023. Meta-analyses utilizing the random effects model were used with odds ratios (OR) and standardized mean differences (SMD).
Meta-analysis comprised eight randomized clinical trials and preclinical studies. Hair growth analysis found a non-significant improvement in hair count (SMD = 0.32, 95 % CI -0.10 to 0.75) and a significant effect on thickness (SMD = 0.92, 95 % CI 0.47 to 1.36). In preclinical studies, probiotics significantly induced hair follicle count (SMD = 3.24, 95 % CI 0.65 to 5.82) and skin thickness (SMD = 2.32, 95 % CI 0.47 to 4.17). VEGF levels increased significantly (SMD = 2.97, 95 % CI 0.80 to 5.13), while IGF-1 showed a non-significant inducement (SMD = 0.53, 95 % CI -4.40 to 5.45). For dandruff control, two studies demonstrated non-significant improvement in adherent dandruff (OR = 1.31, 95 % CI 0.13-13.65) and a significant increase in free dandruff (OR = 5.39, 95 % CI 1.50-19.43). Hair follicle count, VEGF, IGF-1, and adherent dandruff parameters were recorded with high heterogeneity. For the systematic review, probiotics have shown potential in improving hair growth and controlling dandruff through modulation of the immune pathway and gut-hair axis. The Wnt/β-catenin pathway, IGF-1 pathway, and VEGF are key molecular pathways in regulating hair follicle growth and maintenance.
This review found significant aspects exemplified by the properties of probiotics related to promoting hair growth and anti-dandruff effect, which serve as a roadmap for further in-depth studies to make it into pilot scales.
益生菌作为功能性食品来源的潜力发现具有重要的学术价值。本研究通过调查经济和美容行业动态，对学术文章进行了全面综述，以评估益生菌促进头发生长和控制头皮屑的能力。
我们使用PRISMA 2020结合Embase、Pubmed、ClinicalTrials.gov、Scopus和ICTRP数据库，检索截至2023年5月的研究。采用随机效应模型进行荟萃分析，计算比值比（OR）和标准化均值差（SMD）。
荟萃分析纳入了8项随机临床试验和临床前研究。头发生长分析发现，头发数量改善不显著（SMD = 0.32，95%CI -0.10至0.75），但对头发厚度有显著影响（SMD = 0.92，95%CI 0.47至1.36）。在临床前研究中，益生菌显著增加毛囊数量（SMD = 3.24，95%CI 0.65至5.82）和皮肤厚度（SMD = 2.32，95%CI 0.47至4.17）。血管内皮生长因子（VEGF）水平显著升高（SMD = 2.97，95%CI 0.80至5.13），而胰岛素样生长因子-1（IGF-1）的诱导作用不显著（SMD = 0.53，95%CI -4.40至5.45）。对于头皮屑控制，两项研究表明，附着性头皮屑改善不显著（OR = 1.31，95%CI 0.13 - 13.65），而游离性头皮屑显著增加（OR = 5.39，95%CI 1.50至19.43）。毛囊数量、VEGF、IGF-1和附着性头皮屑参数的记录存在高度异质性。在系统评价中，益生菌已显示出通过调节免疫途径和肠-发轴来改善头发生长和控制头皮屑的潜力。Wnt/β-连环蛋白途径、IGF-1途径和VEGF是调节毛囊生长和维持的关键分子途径。
本综述发现了益生菌促进头发生长和抗头皮屑作用相关特性的重要方面，为进一步深入研究并将其扩大到试点规模提供了路线图。
