Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA.
Kaleidoscope Statistics, Athens, Georgia, USA.
J Vet Intern Med. 2024 May-Jun;38(3):1458-1464. doi: 10.1111/jvim.17081. Epub 2024 May 3.
Dogs with congenital intrahepatic portosystemic shunt (IHPSS) are predisposed to gastrointestinal inflammation, ulceration, and bleeding, unlike dogs with congenital extrahepatic portosystemic shunt (EHPSS). Limited information is available about hematologic differences between dogs with IHPSS and dogs with EHPSS.
Compare hemogram variables between dogs with IHPSS and EHPSS. We hypothesized that hematologic variables would differ between the 2 populations, with a higher frequency and severity of anemia and microcytosis in dogs with IHPSS.
Twenty-six client-owned dogs with IHPSS and 35 client-owned dogs with EHPSS.
Retrospective cross-sectional study. Dogs were included if a CBC was performed before shunt attenuation. Contingency analysis was performed to determine if the frequency of clinical signs and of hematologic variables below the reference range differed between groups. Hematologic and selected biochemical variables were compared between groups using an analysis of covariance with age as a covariate.
Gastrointestinal clinical signs (IHPSS, 81% vs EHPSS, 34%; P = .01), anemia (31% vs 6%; P = .01), microcytosis (77% vs 29%; P = .002), and hypochromia (77% vs 49%; P = .03) were more common in dogs with IHPSS than in dogs with EHPSS. Dogs with IHPSS had lower packed cell volume (34% vs 41%, P = .04), hemoglobin concentration (11.5 g/dL vs 13.7 g/dL, P = .03), mean corpuscular volume (57 fL vs 65 fL; P = .001), and mean corpuscular hemoglobin concentration (32 g/dL vs 33 g/dL; P = .04) than dogs with EHPSS.
Dogs with IHPSS had a higher frequency of anemia, microcytosis, and hypochromia and exhibited more gastrointestinal clinical signs.
与先天性肝外门体分流（EHPSS）犬不同，患有先天性肝内门体分流（IHPSS）的犬易患胃肠道炎症、溃疡和出血。关于 IHPSS 犬和 EHPSS 犬之间的血液学差异，目前信息有限。
比较 IHPSS 犬和 EHPSS 犬的血液学变量。我们假设这两个群体的血液学变量会有所不同，IHPSS 犬的贫血和小细胞性贫血的频率和严重程度更高。
26 只患有 IHPSS 的患犬和 35 只患有 EHPSS 的患犬。
回顾性病例对照研究。如果在分流衰减前进行了全血细胞计数（CBC），则将犬纳入研究。使用列联分析确定两组之间的临床症状频率和低于参考范围的血液学变量是否存在差异。使用协方差分析比较两组的血液学和选定的生化变量，并将年龄作为协变量。
胃肠道临床症状（IHPSS，81% vs EHPSS，34%；P=0.01）、贫血（31% vs 6%；P=0.01）、小细胞性贫血（77% vs 29%；P=0.002）和低色素性贫血（77% vs 49%；P=0.03）在 IHPSS 犬中比 EHPSS 犬更常见。IHPSS 犬的红细胞压积（34% vs 41%，P=0.04）、血红蛋白浓度（11.5g/dL vs 13.7g/dL，P=0.03）、平均红细胞体积（57fL vs 65fL；P=0.001）和平均红细胞血红蛋白浓度（32g/dL vs 33g/dL；P=0.04）均低于 EHPSS 犬。
IHPSS 犬贫血、小细胞性贫血和低色素性贫血的频率更高，且表现出更多的胃肠道临床症状。
