Faculty of Pharmacy & Medical Sciences, University of Petra, Amman, 11196, Jordan.
Faculty of Pharmacy, The University of Jordan, Amman, 11942, Jordan.
Probiotics Antimicrob Proteins. 2024 Oct;16(5):1836-1856. doi: 10.1007/s12602-024-10275-7. Epub 2024 May 3.
The complex relationship between probiotics and human health goes beyond their traditional function in gut health, generating considerable interest for their broad potential in disease treatment. This review explores the various functions of probiotics, highlighting their impact on the immune system, their benefits for gut and oral health, their effects on metabolic and neurological disorders, and their emerging potential in cancer therapy. We give significant importance to studying the effects of probiotics on the gut-brain axis, revealing new and non-invasive therapeutic approaches for complex neurological disorders. In addition, we expand the discussion to encompass the impact of probiotics on the gut-liver and gut-lung axes, recognizing their systemic effects and potential in treating respiratory and hepatic conditions. The use of probiotic "cocktails" to improve cancer immunotherapy outcomes indicates a revolutionary approach to oncological treatments. The review explores the specific benefits associated with various strains and the genetic mechanisms that underlie them. This study sets the stage for precision medicine, where probiotic treatments can be tailored to meet the unique needs of each patient. Recent developments in delivery technologies, including microencapsulation and nanotechnology, hold great potential for enhancing the effectiveness and accuracy of probiotic applications in therapeutic settings. This study provides a strong basis for future scientific research and clinical use, promoting the incorporation of probiotics into treatment plans for a wide range of diseases. This expands our understanding of the potential benefits of probiotics in modern medicine.
益生菌与人类健康之间的复杂关系超出了它们在肠道健康方面的传统功能，其在疾病治疗方面的广泛潜力引起了极大的关注。本综述探讨了益生菌的各种功能，强调了它们对免疫系统的影响、对肠道和口腔健康的益处、对代谢和神经紊乱的影响，以及它们在癌症治疗中的新兴潜力。我们非常重视研究益生菌对肠脑轴的影响，为复杂神经紊乱揭示新的非侵入性治疗方法。此外，我们将讨论扩展到包括益生菌对肠-肝和肠-肺轴的影响，认识到它们在治疗呼吸和肝脏疾病方面的全身效应和潜力。益生菌“鸡尾酒”在改善癌症免疫治疗效果方面的应用标志着肿瘤治疗的革命性方法。该综述探讨了与各种菌株相关的具体益处以及它们背后的遗传机制。这项研究为精准医学奠定了基础，其中益生菌治疗可以根据每个患者的独特需求进行定制。包括微胶囊化和纳米技术在内的新型递药技术的发展为提高益生菌在治疗环境中的应用效果和准确性提供了巨大的潜力。本研究为未来的科学研究和临床应用提供了坚实的基础，促进了益生菌在广泛疾病治疗计划中的应用。这扩展了我们对益生菌在现代医学中的潜在益处的理解。
