Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan.
Department of Medical Laboratory Technology, University of Imam Jaafar AL-Sadiq, Baghdad, Iraq.
Naunyn Schmiedebergs Arch Pharmacol. 2024 Oct;397(10):7229-7254. doi: 10.1007/s00210-024-03104-9. Epub 2024 May 3.
The utilization of medicinal plant extracts in therapeutics has been hindered by various challenges, including poor bioavailability and stability issues. Nanovesicular delivery systems have emerged as promising tools to overcome these limitations by enhancing the solubility, bioavailability, and targeted delivery of bioactive compounds from medicinal plants. This review explores the applications of nanovesicular delivery systems in antibacterial and anticancer therapeutics using medicinal plant extracts. We provide an overview of the bioactive compounds present in medicinal plants and their therapeutic properties, emphasizing the challenges associated with their utilization. Various types of nanovesicular delivery systems, including liposomes, niosomes, ethosomes, and solid lipid nanoparticles, among others, are discussed in detail, along with their potential applications in combating bacterial infections and cancer. The review highlights specific examples of antibacterial and anticancer activities demonstrated by these delivery systems against a range of pathogens and cancer types. Furthermore, we address the challenges and limitations associated with the scale-up, stability, toxicity, and regulatory considerations of nanovesicular delivery systems. Finally, future perspectives are outlined, focusing on emerging technologies, integration with personalized medicine, and potential collaborations to drive forward research in this field. Overall, this review underscores the potential of nanovesicular delivery systems for enhancing the therapeutic efficacy of medicinal plant extracts in antibacterial and anticancer applications, while identifying avenues for further research and development.
药用植物提取物在治疗中的应用受到多种挑战的阻碍，包括生物利用度差和稳定性问题。纳米囊泡给药系统作为一种有前途的工具，可以通过提高生物活性化合物的溶解度、生物利用度和靶向递送，来克服这些局限性。本综述探讨了纳米囊泡给药系统在抗菌和抗癌治疗中应用的研究进展，使用了药用植物提取物。我们概述了药用植物中存在的生物活性化合物及其治疗特性，强调了它们利用的相关挑战。详细讨论了各种类型的纳米囊泡给药系统，包括脂质体、非离子型囊泡、醇质体和固体脂质纳米粒等，以及它们在对抗细菌感染和癌症方面的潜在应用。综述强调了这些给药系统在针对各种病原体和癌症类型的抗菌和抗癌活性方面的具体实例。此外，我们还讨论了与纳米囊泡给药系统的规模扩大、稳定性、毒性和监管考虑相关的挑战和限制。最后，概述了未来的研究方向，重点关注新兴技术、与个性化医疗的整合以及潜在的合作，以推动该领域的研究。总的来说，本综述强调了纳米囊泡给药系统在提高药用植物提取物在抗菌和抗癌应用中的治疗效果方面的潜力，同时确定了进一步研究和开发的方向。
