Hassan Hossam, Kandeel Amr, Fahim Manal, ElSood Hanaa Abu, Elghazaly Shereen, Kamel Reham, El Shourbagy Sahar, Afifi Salma, Fattah Mohamed Abdel, Choi Miyoung, Lee Sang Gyu, Rajaguru Vasuki, Han Whiejong
Department of Epidemiology and Surveillance, Preventive Sector, Ministry of Health and Population, Cairo, Egypt.
Department of Global Health and Disease Control, Graduate School of Public Health, Yonsei University, Seoul, South Korea.
PLOS Glob Public Health. 2024 May 3;4(5):e0003152. doi: 10.1371/journal.pgph.0003152. eCollection 2024.
Influenza remains a contributor to substantial global morbidity and mortality. There is very limited data on disease burden in Egypt. The purpose of this study was to estimate the incidence of influenza-associated Severe Acute Respiratory Illness (SARI) in three districts in Gharbia governorate in 2018.
This study Followed the World Health Organization (WHO) manual for estimating disease burden associated with seasonal influenza. The hospital admission database was screened for SARI patients in three districts at Gharbia governorate in 2018. A hospital admission survey (HAS) was used to define the catchment population. The incidence rate estimation was computed as the number of influenza-positive SARI cases per 100,000 population.
A total of 180 SARI cases were identified in the catchment area. The median age was 23 years [IQR: 2-53], and 45% were males. Out of the total SARI cases, 33.3% influenza was confirmed by the laboratory test of RP-PCR. Influenza A(H3N2) virus predominated representing 55.0% of patients, thanA(H1N1) 26.7% and Flu-B virus 18.3%. Influenza prevailed in winter and spring; no deaths from influenza were reported. The annual incidence of influenza-associated SARIs found higher in <2 years (282 /100,000) and ≥65 years patients (215/100,000) at significant level p<0.001.
The WHO Manual for estimating disease burden associated with seasonal influenza was successfully operationalized in the three districts of Gharbia governorate. It can be used in other districts. A considerable burden was associated with influenza viruses requiring hospitalization, especially among the older adult group.
流感仍是全球大量发病和死亡的一个因素。埃及关于疾病负担的数据非常有限。本研究的目的是估计2018年盖勒尤比省三个地区流感相关严重急性呼吸疾病（SARI）的发病率。
本研究遵循世界卫生组织（WHO）关于估计与季节性流感相关疾病负担的手册。对2018年盖勒尤比省三个地区的SARI患者的医院入院数据库进行筛查。采用医院入院调查（HAS）来确定集水区人口。发病率估计值计算为每10万人口中流感阳性SARI病例数。
在集水区共确定了180例SARI病例。中位年龄为23岁[四分位间距：2 - 53岁]，45%为男性。在所有SARI病例中，33.3%通过RP-PCR实验室检测确诊为流感。甲型（H3N2）流感病毒占主导，占患者的55.0%，其次是甲型（H1N1）流感病毒占26.7%，乙型流感病毒占18.3%。流感在冬季和春季流行；未报告流感死亡病例。在<2岁（282/10万）和≥65岁患者（215/10万）中发现流感相关SARI的年发病率较高，p<0.001，差异有统计学意义。
WHO关于估计与季节性流感相关疾病负担的手册在盖勒尤比省的三个地区成功实施。它可用于其他地区。流感病毒导致了相当大的住院负担，尤其是在老年人群体中。
