Ikhlas Muhamad, Ferianto Djonny, Syamsu Salman Ardi, Ganda Idham Jaya, Smaradania Nilam, Sampepajung Elridho, Anggita Citra Azma, Faruk Muhammad
Division of Oncology, Department of Surgery, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia.
Faculty of Medicine, Universitas Alkhairaat, Palu, Indonesia.
Breast Dis. 2024;43(1):93-98. doi: 10.3233/BD-249003.
Breast cancer (BC) cases in Makassar, Indonesia, are on the rise, with 2723 cases recorded in 2018. Tumor cells in the blood indicate metastasis, emphasizing the need for early diagnosis and monitoring. Pleiotrophin (PTN) is associated with various human malignancies, and recent studies suggest a correlation between PTN expression and advanced BC stages; therefore, PTN could serve as an independent predictor of metastasis. This study aimed to determine the correlation between serum PTN level, histopathological grading, and metastasis occurrence in BC patients in Makassar, Indonesia.
This study used an observational cross-sectional design. Pleiotrophin serum levels were examined using enzyme-linked immunosorbent assays. This study used a t-test and ROC curve analysis for the statistical tests.
Of the 64 samples used in this study, metastasis was present in 26 cases and absent in 38 samples. The mean PTN serum levels in metastatic and non-metastatic breast cancer patients were 4.311 and 1.253, respectively. The PTN receiver operating characteristic curve showed an area under the curve of 2.47 ng/dL, which was statistically significant (p < 0.001). A significant relationship was found between PTN level and metastasis (p < 0.001). The correlation coefficient was 0.791, indicating a positive correlation.
This study revealed that the serum PTN level among breast cancer patients had a cut-off value of 2.47 ng/dL. The research established a clear correlation between PTN level and metastasis occurrence in breast cancer patients, indicating a higher likelihood of distant metastasis with elevated PTN concentration.
印度尼西亚望加锡的乳腺癌（BC）病例呈上升趋势，2018年记录了2723例。血液中的肿瘤细胞表明发生了转移，这凸显了早期诊断和监测的必要性。多效生长因子（PTN）与多种人类恶性肿瘤相关，最近的研究表明PTN表达与晚期BC阶段之间存在相关性；因此，PTN可作为转移的独立预测指标。本研究旨在确定印度尼西亚望加锡BC患者血清PTN水平、组织病理学分级与转移发生之间的相关性。
本研究采用观察性横断面设计。使用酶联免疫吸附测定法检测多效生长因子血清水平。本研究使用t检验和ROC曲线分析进行统计检验。
本研究使用的64个样本中，26例存在转移，38个样本未发生转移。转移性和非转移性乳腺癌患者的平均PTN血清水平分别为4.311和1.253。PTN的受试者工作特征曲线显示曲线下面积为2.47 ng/dL，具有统计学意义（p < 0.001）。发现PTN水平与转移之间存在显著关系（p < 0.001）。相关系数为0.791，表明呈正相关。
本研究表明，乳腺癌患者的血清PTN水平临界值为2.47 ng/dL。该研究确定了PTN水平与乳腺癌患者转移发生之间的明确相关性，表明PTN浓度升高时远处转移的可能性更高。
