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针灸治疗重症肌无力：一项系统评价与Meta分析

Acupuncture and moxibustion treatment for myasthenia gravis: A systematic review and meta-analysis.

作者信息

Lu Ying, Li Jian, Yu Ting, Wu Chunlan, You Yi, Wang Changde, Liu Xiaoying

机构信息

Shanghai TCM-Integrated Hospital, Shanghai University of TCM, Shanghai, China.

出版信息

Medicine (Baltimore). 2024 May 3;103(18):e37961. doi: 10.1097/MD.0000000000037961.

DOI:10.1097/MD.0000000000037961
PMID:38701271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11062737/
Abstract

BACKGROUND

Myasthenia gravis (MG) is a common autoimmune disease that often involves the skeletal muscle of the whole body and seriously affects patients' quality of life. Acupuncture and moxibustion treatment of MG has unique advantages, the aim is to evaluate the clinical effect of acupuncture and moxibustion on MG.

METHODS

The literature on acupuncture and moxibustion treating MG in PubMed, CochraneLibrary, EMBASE, SCI, China Academic Journals full-text database, China Biology Medicine disc, VIP and Wanfang database were searched through computers from the establishment of the database to December 2022.

RESULTS

A total of 11 studies were included, involving 658 patients, where 330 in the treatment group and 328 in the control group. The results of the meta-analysis showed that the treatment group performed better than the control group in improving the total clinical response rate (OR = 3.26, 95%[2.04,5.21], P < .01). Additionally, the treatment group outperformed the control group in raising the absolute clinical score (MD = -3.48, 95%CI[-5.17, -1.78], P < .01). However, there was no significant difference between the treatment group and the control group in improving the level of serum interleukin-6 receptor (MD = -1.45,95%CI[-6.85,3.95], P > .05) and OMG quantitative score (MD = -2.16,95%CI[-4.85,0.52], P > .05). The total clinical effective rate was tested for publication bias, which showed that the 2 sides of the funnel plot were asymmetrical, suggesting the possible existence of publication bias.

CONCLUSION

Acupuncture and moxibustion has a good effect on MG, which is better than conventional Western medicine in improving the total clinical effective rate and absolute clinical score.

摘要

背景

重症肌无力（MG）是一种常见的自身免疫性疾病，常累及全身骨骼肌，严重影响患者生活质量。针灸治疗MG具有独特优势，旨在评估针灸对MG的临床疗效。

方法

通过计算机检索PubMed、CochraneLibrary、EMBASE、SCI、中国学术期刊全文数据库、中国生物医学光盘数据库、维普数据库和万方数据库中自建库至2022年12月关于针灸治疗MG的文献。

结果

共纳入11项研究，涉及658例患者，其中治疗组330例，对照组328例。Meta分析结果显示，治疗组在提高总临床有效率方面优于对照组（OR = 3.26，95%[2.04,5.21]，P <.01）。此外，治疗组在提高绝对临床评分方面优于对照组（MD = -3.48，95%CI[-5.17, -1.78]，P <.01）。然而，治疗组与对照组在改善血清白细胞介素-6受体水平（MD = -1.45,95%CI[-6.85,3.95]，P >.05）和OMG定量评分（MD = -2.16,95%CI[-4.85,0.52]，P >.05）方面无显著差异。对总临床有效率进行发表偏倚检验，结果显示漏斗图两侧不对称，提示可能存在发表偏倚。

结论

针灸治疗MG疗效良好，在提高总临床有效率和绝对临床评分方面优于传统西药。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b6b/11062737/d72aef7156d2/medi-103-e37961-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b6b/11062737/5f9ef31d5a39/medi-103-e37961-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b6b/11062737/55bceb2a44b0/medi-103-e37961-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b6b/11062737/2e7086be0b85/medi-103-e37961-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b6b/11062737/69768e9d8375/medi-103-e37961-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b6b/11062737/d72aef7156d2/medi-103-e37961-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b6b/11062737/5f9ef31d5a39/medi-103-e37961-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b6b/11062737/55bceb2a44b0/medi-103-e37961-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b6b/11062737/2e7086be0b85/medi-103-e37961-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b6b/11062737/69768e9d8375/medi-103-e37961-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b6b/11062737/d72aef7156d2/medi-103-e37961-g005.jpg

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Myasthenia Gravis: Epidemiology, Pathophysiology and Clinical Manifestations.重症肌无力：流行病学、病理生理学及临床表现
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