Pinel A, Guillet C, Capel F, Pouget M, De Antonio M, Pereira B, Topinkova E, Eglseer D, Barazzoni R, Cruz-Jentoft A J, Schoufour J D, Weijs P J M, Boirie Y
University of Clermont Auvergne, Human Nutrition Unit, INRAe, CRNH Auvergne, Clermont-Ferrand, France.
University of Clermont Auvergne, Human Nutrition Unit, INRAe, CRNH Auvergne, Clermont-Ferrand, France.
Clin Nutr. 2024 Jun;43(6):1414-1424. doi: 10.1016/j.clnu.2024.04.033. Epub 2024 Apr 24.
Sarcopenic obesity (SO) is defined as the combination of excess fat mass (obesity) and low skeletal muscle mass and function (sarcopenia). The identification and classification of factors related to SO would favor better prevention and diagnosis. The present article aimed to (i) define a list of factors related with SO based on literature analysis, (ii) identify clinical conditions linked with SO development from literature search and (iii) evaluate their relevance and the potential research gaps by consulting an expert panel. From 4746 articles screened, 240 articles were selected for extraction of the factors associated with SO. Factors were classified according to their frequency in the literature. Clinical conditions were also recorded. Then, they were evaluated by a panel of expert for evaluation of their relevance in SO development. Experts also suggested additional factors. Thirty-nine unique factors were extracted from the papers and additional eleven factors suggested by a panel of experts in the SO field. The frequency in the literature showed insulin resistance, dyslipidemia, lack of exercise training, inflammation and hypertension as the most frequent factors associated with SO whereas experts ranked low spontaneous physical activity, protein and energy intakes, low exercise training and aging as the most important. Although literature and expert panel presented some differences, this first list of associated factors could help to identify patients at risk of SO. Further work is needed to confirm the contribution of factors associated with SO among the population overtime or in randomized controlled trials to demonstrate causality.
肌少症性肥胖（SO）被定义为过量脂肪量（肥胖）与低骨骼肌量和功能（肌少症）的结合。识别和分类与SO相关的因素将有助于更好地预防和诊断。本文旨在：（i）基于文献分析确定与SO相关的因素列表；（ii）通过文献检索确定与SO发生相关的临床情况；（iii）通过咨询专家小组评估这些因素的相关性以及潜在的研究空白。在筛选的4746篇文章中，选取了240篇用于提取与SO相关的因素。根据这些因素在文献中的出现频率进行分类，同时记录临床情况。然后，由一个专家小组对其在SO发生中的相关性进行评估。专家们还提出了其他因素。从论文中提取了39个独特的因素，并由SO领域的专家小组另外提出了11个因素。文献中的出现频率显示，胰岛素抵抗、血脂异常、缺乏运动训练、炎症和高血压是与SO相关的最常见因素，而专家们认为低自发体力活动、蛋白质和能量摄入、低运动训练以及衰老最为重要。尽管文献和专家小组的意见存在一些差异，但这一相关因素的初步列表有助于识别有SO风险的患者。需要进一步开展工作，以确认在人群中长期或在随机对照试验中与SO相关的因素的作用，从而证明因果关系。
