Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, United States.
Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, United States.
Virus Res. 2024 Jul;345:199384. doi: 10.1016/j.virusres.2024.199384. Epub 2024 May 7.
Due to the limited size of viral genomes, hijacking host machinery by the viruses taking place throughout the virus life cycle is inevitable for the survival and proliferation of the virus in the infected hosts. Recent reports indicated that Annexin A2 (AnxA2), a calcium- and lipid-binding cellular protein, plays an important role as a critical regulator in various steps of the virus life cycle. The multifarious AnxA2 functions in cells, such as adhesion, adsorption, endocytosis, exocytosis, cell proliferation and division, inflammation, cancer metastasis, angiogenesis, etc., are intimately related to the various clinical courses of viral infection. Ubiquitous expression of AnxA2 across multiple cell types indicates the broad range of susceptibility of diverse species of the virus to induce disparate viral disease in various tissues, and intracellular expression of AnxA2 in the cytoplasmic membrane, cytosol, and nucleus suggests the involvement of AnxA2 in the regulation of the different stages of various virus life cycles within host cells. However, it is yet unclear as to the molecular processes on how AnxA2 and the infected virus interplay to regulate virus life cycles and thereby the virus-associated disease courses, and hence elucidation of the molecular mechanisms on AnxA2-mediated virus life cycle will provide essential clues to develop therapeutics deterring viral disease.
由于病毒基因组的大小有限，病毒在整个生命周期中劫持宿主机制对于病毒在感染宿主中的生存和增殖是不可避免的。最近的报告表明，膜联蛋白 A2（AnxA2）是一种钙和脂质结合的细胞蛋白，作为病毒生命周期各个步骤的关键调节剂，起着重要作用。AnxA2 在细胞中的多种功能，如黏附、吸附、内吞作用、胞吐作用、细胞增殖和分裂、炎症、癌症转移、血管生成等，与病毒感染的各种临床过程密切相关。AnxA2 在多种细胞类型中的广泛表达表明，多种病毒对不同组织的不同病毒疾病具有广泛的易感性，并且细胞质膜、细胞质和核内的细胞内 AnxA2 表达表明 AnxA2 参与了不同阶段的不同病毒生命周期的调节在宿主细胞内。然而，目前尚不清楚 AnxA2 和感染病毒之间是如何相互作用来调节病毒生命周期，从而调节病毒相关疾病过程的，因此阐明 AnxA2 介导的病毒生命周期的分子机制将为开发阻止病毒疾病的治疗方法提供重要线索。
