Vedeler Anni, Tartaglia Gian Gaetano, Pastore Annalisa
Neurotargeting Group, Department of Biomedicine, University of Bergen, Bergen, Norway.
Center for Human Technologies, Istituto Italiano di Tecnologia, Genova, Italy.
Bioessays. 2025 Jul;47(7):e70019. doi: 10.1002/bies.70019. Epub 2025 May 12.
Annexins are a protein family well known to bind to phospholipids in a calcium-dependent way. They are involved in several different crucial cellular processes such as cell division, calcium signaling, membrane repair, vesicle trafficking, and apoptosis. Although RNA binding for some members of the family was reported long ago, it was only recently that it was shown that a common feature of the family is also the ability to bind RNA, a discovery that has added significantly to our perception of the cellular role of these proteins. In the present review, we discuss the properties of annexins under an updated light and the current knowledge on the RNA binding properties of annexins. We then focus specifically on annexin A11, because this is a less characterized member of the family but, at the same time, a potentially important component of the mRNA transport machinery in neurons. We hope to offer to the reader a more complete picture of the annexins' binding properties and new tools to evaluate the multifaceted functions of this important protein family.
膜联蛋白是一个众所周知的蛋白质家族，它以钙依赖的方式与磷脂结合。它们参与多种不同的关键细胞过程，如细胞分裂、钙信号传导、膜修复、囊泡运输和细胞凋亡。尽管该家族的一些成员与RNA结合的现象早在很久以前就有报道，但直到最近才发现该家族的一个共同特征也是能够结合RNA，这一发现极大地丰富了我们对这些蛋白质细胞作用的认识。在本综述中，我们以更新的视角讨论膜联蛋白的特性以及目前关于膜联蛋白RNA结合特性的知识。然后我们特别关注膜联蛋白A11，因为它是该家族中一个研究较少的成员，但同时也是神经元中mRNA运输机制的一个潜在重要组成部分。我们希望为读者提供关于膜联蛋白结合特性的更完整图景以及评估这个重要蛋白质家族多方面功能的新工具。
