Institute and Comprehensive Centre for Inflammation Medicine, University Hospital Schleswig Holstein (UKSH), Campus Lübeck, Lübeck, Germany.
Department of Dermatology, Allergology and Venerology, Section for Inflammatory Medicine, UKSH, Campus Lübeck, Lübeck, Germany.
Clin Exp Dermatol. 2024 Oct 24;49(11):1405-1412. doi: 10.1093/ced/llae164.
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease characterized by intense itch, and impacting heavily on patients' and caregivers' quality of life. Its clinical presentation is accompanied by a variety of comorbidities associated with type 2 inflammation, such as asthma, hay fever and food allergies. However, current data on cardiovascular comorbidities are inconsistent.
To identify the risk of cardiovascular diseases (CVDs) in patients with AD.
Data from electronic health records of 1 070 965 patients with AD and equally distributed propensity-score matched controls were retrieved from the US Collaborative Network, part of the federated TriNetX network. Hazard ratios (HRs) for the risk of onset of CVDs with a prevalence of ≥ 1% in both cohorts within 20 years after diagnosis were determined.
In total, 55 CVDs belonging to 8 major cardiovascular groups were identified. Of those, 53 diagnoses displayed a significantly increased risk in patients with AD. Different diagnoses of heart failure and heart disease were found most often, followed by valve insufficiencies, arrhythmia, tachycardia, atrial fibrillation and flutter, but also major adverse cardiovascular events and venous thromboembolism. The highest HRs were displayed by the individual diagnoses of venous insufficiency, atherosclerosis of native arteries of the extremities, and unspecified diastolic (congestive) heart failure.
AD is associated with an increased risk for multiple CVDs.
特应性皮炎（AD）是一种慢性复发性炎症性皮肤病，其特征为剧烈瘙痒，严重影响患者和护理人员的生活质量。其临床表现伴有多种与 2 型炎症相关的合并症，如哮喘、花粉热和食物过敏。然而，目前关于心血管合并症的数据并不一致。
确定特应性皮炎患者发生心血管疾病（CVD）的风险。
从美国协作网络（TriNetX 联邦网络的一部分）的电子健康记录中检索了 1070965 名特应性皮炎患者和按倾向评分匹配的对照组的数据。在诊断后 20 年内，在两个队列中发病率≥1%的 CVD 风险的风险比（HR）被确定。
共确定了 55 种心血管疾病，属于 8 个主要心血管组。其中，53 种诊断显示特应性皮炎患者的风险显著增加。最常发现的是心力衰竭和心脏病的不同诊断，其次是瓣膜功能不全、心律失常、心动过速、心房颤动和扑动，但也有主要不良心血管事件和静脉血栓栓塞。静脉功能不全、下肢固有动脉粥样硬化和未特指的舒张性（充血性）心力衰竭的个别诊断显示出最高的 HR。
AD 与多种 CVD 的风险增加相关。
