Department of Internal Medicine, Faculty of Medicine, Tehran branch, Islamic Azad University, Tehran, Iran.
Radiology Department, Faculty of Medicine, Guilan University of Medical, Rasht, Iran.
Pathol Res Pract. 2024 Jun;258:155289. doi: 10.1016/j.prp.2024.155289. Epub 2024 Apr 2.
Radiotherapy (RT) is a frequently used treatment for cervical cancer, effectively decreasing the likelihood of the disease returning in the same area and extending the lifespan of individuals with cervical cancer. Nevertheless, the primary reason for treatment failure in cancer patients is the cancer cells' resistance to radiation therapy (RT). Long non-coding RNAs (LncRNAs) are a subset of RNA molecules that do not code for proteins and are longer than 200 nucleotides. They have a significant impact on the regulation of gastrointestinal (GI) cancers biological processes. Recent research has shown that lncRNAs have a significant impact in controlling the responsiveness of GI cancer to radiation. This review provides a concise overview of the composition and operation of lncRNAs as well as the intricate molecular process behind radiosensitivity in GI cancer. Additionally, it compiles a comprehensive list of lncRNAs that are linked to radiosensitivity in such cancers. Furthermore, it delves into the potential practical implementation of these lncRNAs in modulating radiosensitivity in GI cancer.
放射治疗（RT）是宫颈癌常用的治疗方法，能有效降低疾病在同一部位复发的可能性，并延长宫颈癌患者的寿命。然而，癌症患者治疗失败的主要原因是癌细胞对放射治疗（RT）的耐药性。长链非编码 RNA（lncRNA）是一类不编码蛋白质且长度大于 200 个核苷酸的 RNA 分子。它们对胃肠道（GI）癌症的生物学过程的调控有重要影响。最近的研究表明，lncRNA 在控制 GI 癌症对放射的反应性方面具有重要作用。这篇综述简要概述了 lncRNA 的组成和作用，以及 GI 癌症放射敏感性背后复杂的分子过程。此外，它还列出了与这些癌症放射敏感性相关的 lncRNA 的综合清单。此外，它还深入探讨了这些 lncRNA 在调节 GI 癌症放射敏感性方面的潜在实际应用。
