Sechserová M, Sechser T, Rasková H, Elis J, Vanĕcek J, Polák L, Matĕjovská D, Raska K
Arzneimittelforschung. 1979;29(5):804-7.
Acetylsalicylic acid (ASA) was administered by oral route to calves and mice. A comparison of plasma levels of salicylates and salicyluric acid was performed in healthy and diarrhoic calves. The calves were infected with E. coli enterotoxin producing strains. During the 6 h observation period increased levels of salicylates were found in all age groups of calves (1-60 days). There were no significant differences in salicyluric acid plasma levels between controls and diarrhoic animals. Intravenous injection of cholera toxin in mice caused lower levels of total salicylates, but increased levels of salicylic acid and salicyluric acid. The importance of adequate animal model is discussed.
将乙酰水杨酸（ASA）经口服途径给予小牛和小鼠。对健康小牛和腹泻小牛的血浆中水杨酸盐和水杨尿酸水平进行了比较。小牛感染了产大肠杆菌肠毒素的菌株。在6小时的观察期内，所有年龄组（1 - 60天）的小牛体内水杨酸盐水平均升高。对照组和腹泻动物的血浆水杨尿酸水平无显著差异。给小鼠静脉注射霍乱毒素导致总水杨酸盐水平降低，但水杨酸和水杨尿酸水平升高。文中讨论了合适动物模型的重要性。
