Holzmann H, Morsches B, Benes P
Arzneimittelforschung. 1979;29(8):1180-3.
Absorption and clinical efficacy of a preparation containing 20% benzoyl peroxide were studied in 20 patients with leg ulcers of varying etiology. Benzoic acid formed from benzoyl peroxide on penetration through the skin cannot be demonstrated in the plasma until three days after commencing application at the earliest. This indicates a building up of deposits of benzoyl peroxide in the skin. The plasma benzoic acid levels in all patients amounted to less than 5 mumol/l and is therefore toxicologically inoffensive. Clinically, the known therapeutic effects of benzoyl peroxide were confirmed. Neither sensitization nor allergic reactions were found in the 20 patients taking part in this study.
对20例病因各异的腿部溃疡患者，研究了含20%过氧化苯甲酰制剂的吸收情况及临床疗效。最早在开始用药三天后，才能在血浆中检测到过氧化苯甲酰穿透皮肤后形成的苯甲酸。这表明过氧化苯甲酰在皮肤中逐渐蓄积。所有患者血浆中苯甲酸水平均低于5微摩尔/升，因此在毒理学上无不良影响。临床上，过氧化苯甲酰已知的治疗效果得到了证实。参与本研究的20例患者均未发现致敏或过敏反应。
