Seubert S, Seubert A, Ippen H
Hautarzt. 1984 Sep;35(9):455-8.
Benzoyl peroxide preparations have proven to be effective agents in the treatment of acne. In comparison to the numerous clinical communications, very few reports exist concerning the pharmacokinetics of benzoyl peroxide. The benzoyl peroxide content of abraded horny layers and its metabolite benzoic acid were investigated by high-pressure liquid chromatography after application (1-2 min) of emulsion containing benzoyl peroxide. It was found that benzoyl peroxide penetrates the stratum corneum very quickly where it is rapidly degraded to benzoic acid. No benzoyl peroxide depot in the stratum corneum could be demonstrated.
过氧化苯甲酰制剂已被证明是治疗痤疮的有效药物。与众多临床报道相比，关于过氧化苯甲酰药代动力学的报道非常少。在应用含过氧化苯甲酰的乳液（1 - 2分钟）后，通过高压液相色谱法研究了磨损角质层中的过氧化苯甲酰含量及其代谢产物苯甲酸。结果发现，过氧化苯甲酰能非常迅速地穿透角质层，并在其中迅速降解为苯甲酸。未在角质层中发现过氧化苯甲酰储存库。
