Settipane G A, Klein D E
N Engl Reg Allergy Proc. 1985 Fall;6(4):363-6. doi: 10.2500/108854185779109124.
Seventy-eight consecutive patients with non allergic rhinitis (negative allergy skin tests) were evaluated and classified as to possible causes using strict criteria. Sixty-one percent had vasomotor rhinitis (VMR), 33% had non allergic rhinitis with eosinophilia syndrome (NARES), 16% had sinusitis, 12% had a possible hidden allergy (elevated IgE), 4% had blood eosinophilic non allergic rhinitis (BENAR) and 2% had hypothyroidism. Some overlapping of diagnosis was present. Five per cent or greater eosinophils in the nasal smear appeared to be enough to consider the diagnosis of NARES. Sinusitis tended to be more significant in the NARES group compared to VMR. BENARS may be a new syndrome. It differs from NARES in that BENARS has markedly elevated blood eosinophilia and possibly no associated sinusitis. It is similar to NARES in that it has negative allergy skin test, normal serum IgE, and eosinophils in nasal secretions. Other causes of eosinophilia were excluded in our NARES and BENARS groups.
对78例非过敏性鼻炎（皮肤过敏试验阴性）患者进行了连续评估，并使用严格标准按可能病因进行分类。61%患有血管运动性鼻炎（VMR），33%患有嗜酸性粒细胞增多综合征的非过敏性鼻炎（NARES），16%患有鼻窦炎，12%可能存在隐匿性过敏（IgE升高），4%患有血液嗜酸性粒细胞性非过敏性鼻炎（BENAR），2%患有甲状腺功能减退症。存在一些诊断重叠情况。鼻涂片嗜酸性粒细胞占比5%或更高似乎足以考虑诊断为NARES。与VMR相比，鼻窦炎在NARES组中往往更为显著。BENAR可能是一种新综合征。它与NARES的不同之处在于BENAR血液嗜酸性粒细胞明显升高且可能无相关鼻窦炎。它与NARES的相似之处在于皮肤过敏试验阴性、血清IgE正常且鼻分泌物中有嗜酸性粒细胞。在我们的NARES和BENAR组中排除了嗜酸性粒细胞增多的其他病因。
