Wu Danjun, Ji Weili, Xu Shumin, Li Yazhen, Ji Yaning, Fu Kaili, Yang Gensheng
College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Int J Pharm. 2024 Jun 10;658:124203. doi: 10.1016/j.ijpharm.2024.124203. Epub 2024 May 4.
Most nanomedicines with suitable sizes (normally 100-200 nm) exhibit favorable accumulation in the periphery of tumors but hardly penetrate into deep tumors. Effective penetration of nanomedicines requires smaller sizes (less than 30 nm) to overcome the elevated tumor interstitial fluid pressure. Moreover, integrating an efficient diagnostic agent in the nanomedicines is in high demand for precision theranostics of tumors. To this end, a near-infrared light (NIR) -triggered size-shrinkable micelle system (FeO@AuNFs/DOX-M) coloaded antitumor drug doxorubicin (DOX) and biomodal imaging agent magnetic gold nanoflower (FeO@AuNFs) was developed to achieve efficient theranostic of tumors. Upon the accumulation of FeO@AuNFs/DOX-M in the tumor periphery, a NIR laser was irradiated near the tumor sites, and the loaded FeO@Au NFs could convert the light energy to heat, which triggered the cleavage of DOX-M to the ultra-small micelles (∼5 nm), thus realizing the deep penetration of micelles and on-demand drug release. Moreover, FeO@AuNFs in the micelles could also be used as CT/MRI dual-modal contrast agent to "visualize" the tumor. Up to 92.6 % of tumor inhibition was achieved for the developed FeO@AuNFs/DOX-M under NIR irradiation. This versatile micelle system provided a promising drug carrier platform realizing efficient tumor dual-modal diagnosis and photothermal-chemotherapy integration.
大多数尺寸合适（通常为100-200纳米）的纳米药物在肿瘤周边表现出良好的聚集，但很难渗透到肿瘤深部。纳米药物的有效渗透需要更小的尺寸（小于30纳米）以克服升高的肿瘤间质液压力。此外，在纳米药物中整合高效诊断剂对于肿瘤的精确治疗诊断具有很高的需求。为此，开发了一种近红外光（NIR）触发的尺寸可收缩胶束系统（FeO@AuNFs/DOX-M），其共负载抗肿瘤药物阿霉素（DOX）和双模态成像剂磁性金纳米花（FeO@AuNFs），以实现肿瘤的高效治疗诊断。当FeO@AuNFs/DOX-M在肿瘤周边聚集后，在肿瘤部位附近照射近红外激光，负载的FeO@Au NFs可将光能转化为热能，触发DOX-M裂解为超小胶束（约5纳米），从而实现胶束的深部渗透和按需药物释放。此外，胶束中的FeO@AuNFs还可作为CT/MRI双模态造影剂来“可视化”肿瘤。在近红外照射下，所开发的FeO@AuNFs/DOX-M实现了高达92.6%的肿瘤抑制率。这种多功能胶束系统提供了一个有前景的药物载体平台，可实现高效的肿瘤双模态诊断和光热化疗一体化。
