NanoBioMedical Centre, Adam Mickiewicz University, Wszechnicy Piastowskiej 3, 61-614 Poznan, Poland.
Institute of Technology and Chemical Engineering, Poznan University of Technology, ul. Berdychowo 4, 60-965 Poznan, Poland.
Environ Res. 2024 Jul 1;252(Pt 3):119068. doi: 10.1016/j.envres.2024.119068. Epub 2024 May 4.
Cellulose acetate membranes exhibit a potential to be applied in hemodialysis. However, their performance is limited by membrane fouling and a lack of antibacterial properties. In this research, copper oxide (I) nanoparticles were fabricated in situ into a cellulose acetate matrix in the presence of polyvinylpyrrolidone (pore-forming agent) and sulfobetaine (stabilising agent) to reduce the leakage of copper ions from nano-enhanced membranes. The influence of nanoparticles on the membrane structure and their antibacterial and antifouling properties were investigated. The results showed that incorporating CuO NPs imparted significant antibacterial properties against Staphylococcus aureus and fouling resistance under physiological conditions. The CuO NPs-modified membrane could pave the way for potential dialysis applications.
醋酸纤维素膜在血液透析中有应用潜力。然而，其性能受到膜污染和缺乏抗菌性能的限制。在这项研究中，氧化铜（I）纳米颗粒在存在聚乙烯吡咯烷酮（成孔剂）和磺酸甜菜碱（稳定剂）的情况下被原位制备到醋酸纤维素基质中，以减少纳米增强膜中铜离子的泄漏。研究了纳米颗粒对膜结构及其抗菌和抗污染性能的影响。结果表明，纳米氧化铜赋予了对金黄色葡萄球菌的显著抗菌性能，并在生理条件下具有抗污染性。改性后的氧化铜纳米颗粒膜为潜在的透析应用铺平了道路。
