Department of Pediatrics, Stanford University School of Medicine, 291 Campus Drive Li Ka Shing Building, Stanford, CA 94305, USA.
Clinical Epidemiology Program, Ottawa Hospital Research Institute, Centre for Practice Changing Research, 501 Smyth Road, Box 201-B, Ottawa, Ontario, Canada K1H 8L6; School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Ottawa, Ontario, Canada K1G 5Z3.
Clin Perinatol. 2024 Jun;51(2):411-424. doi: 10.1016/j.clp.2024.02.012. Epub 2024 Apr 4.
Preterm birth (PTB) is a leading cause of morbidity and mortality in children aged under 5 years globally, especially in low-resource settings. It remains a challenge in many low-income and middle-income countries to accurately measure the true burden of PTB due to limited availability of accurate measures of gestational age (GA), first trimester ultrasound dating being the gold standard. Metabolomics biomarkers are a promising area of research that could provide tools for both early identification of high-risk pregnancies and for the estimation of GA and preterm status of newborns postnatally.
早产（PTB）是全球 5 岁以下儿童发病和死亡的主要原因，在资源匮乏地区尤其如此。由于缺乏准确的孕周测量方法，许多低收入和中等收入国家都难以准确衡量 PTB 的真实负担，而头三个月超声检查是金标准。代谢组学生物标志物是一个很有前途的研究领域，它可以为高危妊娠的早期识别以及新生儿出生后 GA 和早产状况的估计提供工具。
