Nuffield Department of Women's & Reproductive Health, Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford OX3 9DU, UK.
Department of Obstetrics and Gynaecology, Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.
Clin Perinatol. 2024 Jun;51(2):475-495. doi: 10.1016/j.clp.2024.02.014. Epub 2024 Apr 4.
Preterm birth (PTB) is a complex syndrome traditionally defined by a single parameter, namely, gestational age at birth (ie, ˂37 weeks). This approach has limitations for clinical usefulness and may explain the lack of progress in identifying cause-specific effective interventions. The authors offer a framework for a functional taxonomy of PTB based on (1) conceptual principles established a priori; (2) known etiologic factors; (3) specific, prospectively identified obstetric and neonatal clinical phenotypes; and (4) postnatal follow-up of growth and development up to 2 years of age. This taxonomy includes maternal, placental, and fetal conditions routinely recorded in data collection systems.
早产（PTB）是一种复杂的综合征，传统上通过单一参数定义，即出生时的胎龄（即<37 周）。这种方法在临床应用上存在局限性，可能解释了在确定针对特定病因的有效干预措施方面缺乏进展的原因。作者提出了一种基于以下内容的早产功能分类框架：(1) 预先确定的概念原则；(2) 已知的病因因素；(3) 特定的、前瞻性确定的产科和新生儿临床表型；(4) 出生后至 2 岁的生长和发育随访。该分类法包括在数据收集系统中常规记录的母体、胎盘和胎儿情况。
