Hu Jie, Ouyang Lin, Li Jinxiu, Li Xia, Zhong Yanjun, Hou Can
Critical Care Medicine Center, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
National Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, Key Laboratory Diseases Immunology, Ministry of Education, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 May 1;17:1903-1909. doi: 10.2147/DMSO.S450489. eCollection 2024.
To investigate the potential prognostic value of mean blood glucose (MBG) in hospital for prognosis of COVID-19 adult patients in the intensive unit care unit (ICU).
A single-site and retrospective study enrolled 107 patients diagnosed as COVID-19 from department of critical care medicine in the Second Xiangya Hospital between October 2022 and June 2023. Demographic information including glucose during ICU hospitalization, comorbidity, clinical data, types of medications and treatment, and clinical outcome were collected. The multivariate logistic and cox regression was used to explore the relationship between blood glucose changes and clinical outcomes of COVID-19 during ICU stay.
In total, 107 adult patients confirmed with COVID-19 were included. Multivariate logistic regression results showed an increase in MBG was associated with ICU mortality rate. Compared with normal glucose group (MBG <= 7.8 mmol/L), the risk of ICU mortality, 7-day mortality and 28-day mortality from COVID-19 were significantly increased in high glucose group (MBG >7.8mmol/L).
MBG level during ICU hospitalization was strongly correlated to all-cause mortality and co-infection in COVID-19 patients. These findings further emphasize the importance of overall glucose management in severe cases of COVID-19.
探讨住院期间平均血糖（MBG）对重症监护病房（ICU）中成人新型冠状病毒肺炎（COVID-19）患者预后的潜在预测价值。
一项单中心回顾性研究纳入了2022年10月至2023年6月期间在中南大学湘雅二医院重症医学科确诊为COVID-19的107例患者。收集患者的人口统计学信息，包括在ICU住院期间的血糖、合并症、临床资料、用药及治疗类型以及临床结局。采用多因素logistic回归和Cox回归分析探讨ICU住院期间血糖变化与COVID-19患者临床结局之间的关系。
共纳入107例确诊为COVID-19的成年患者。多因素logistic回归结果显示，MBG升高与ICU死亡率相关。与血糖正常组（MBG≤7.8 mmol/L）相比，高血糖组（MBG>7.8 mmol/L）的COVID-19患者发生ICU死亡、7天死亡和28天死亡的风险显著增加。
ICU住院期间的MBG水平与COVID-19患者的全因死亡率和合并感染密切相关。这些发现进一步强调了COVID-19重症病例中全面血糖管理的重要性。
