Serviço de Medicina Nuclear, Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, Brasil.
Seção de Cirurgia Abdominopélvica, Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, Brasil.
Arch Endocrinol Metab. 2024 May 6;68:e230013. doi: 10.20945/2359-4292-2023-0013.
Neuroendocrine tumors (NETs) are a set of diseases that originate from neuroendocrine cells, which comprises a diffuse endocrine system present in various organs of the body. These tumors are more frequent in the gastrointestinal tract (70%) and the bronchopulmonary system (20%-30%). A NET incidence rate of 1-5 per 100,000 inhabitants has been estimated for several European countries and the USA employing 20 years of data. However, no comprehensive studies on this rare neoplasm are available in Brazil. In this context, the aim of this study was to characterize the epidemiological NET profile in the country.
This is a retrospective descriptive observational study based on data from Hospital Cancer Records available at the Brazilian National Cancer Institute and the São Paulo Oncocentro Foundation. Demographic, clinical and treatmentrelated variables were analyzed from selected cases employing descriptive statistics.
A total of 15,859 cases were identified, most occurring in males (53.4%) and in individuals under 65 years old (63.3%). Small cell carcinoma was the most frequent histological type (46.7%). Bronchopulmonary tumors were the most frequent NETs, followed by pancreatic tumors, with cases mostly concentrated in high complexity centers in the Brazilian Southeast and treated mainly with surgery and chemotherapy, with over half of the patients diagnosed in advanced stages of the disease.
神经内分泌肿瘤（NETs）是一组起源于神经内分泌细胞的疾病，这些细胞构成了存在于人体各种器官中的弥散内分泌系统。这些肿瘤在胃肠道（70%）和支气管肺系统（20%-30%）中更为常见。据估计，使用 20 年的数据，几个欧洲国家和美国的 NET 发病率为每 10 万人中有 1-5 人。然而，巴西尚无关于这种罕见肿瘤的综合研究。在这种情况下，本研究的目的是描述巴西的神经内分泌肿瘤流行病学特征。
这是一项基于巴西国家癌症研究所和圣保罗肿瘤中心基金会的医院癌症记录中数据的回顾性描述性观察研究。采用描述性统计方法对选定病例的人口统计学、临床和治疗相关变量进行分析。
共确定了 15859 例病例，大多数发生在男性（53.4%）和 65 岁以下的人群中（63.3%）。小细胞癌是最常见的组织学类型（46.7%）。支气管肺肿瘤是最常见的 NETs，其次是胰腺肿瘤，病例主要集中在巴西东南部的高复杂性中心，主要采用手术和化疗治疗，超过一半的患者在疾病晚期被诊断。
