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氟中毒对哺乳动物雌性生殖系统的影响:一项荟萃分析。

Effects of Fluoride Toxicity on Female Reproductive System of Mammals: A Meta-Analysis.

作者信息

Fishta Aditi, Thakur Ruhi, Sharma Krishan Chander, Thakur Neha, Patial Bhavna

机构信息

School of Biological and Environmental Sciences, Shoolini University, Solan, 173229, India.

M.S. Swaminathan School of Agricultural Sciences, Shoolini University, Solan, India.

出版信息

Biol Trace Elem Res. 2025 Feb;203(2):646-669. doi: 10.1007/s12011-024-04203-7. Epub 2024 May 6.

DOI:10.1007/s12011-024-04203-7
PMID:38709367
Abstract

Considerable integrative efforts have been made to investigate the effects of fluoride on female reproductive organs since the last years. The ingestion of fluoride causes adverse effects on human health like causing skeletal fluorosis, dental fluorosis, bone fractures, kidney problems, decrease birth rates, weakening of thyroid functionality, and impair intelligence, particularly in children. In this review, we discuss the adverse effects of fluoride on female reproductive organs and presented certain remedies. A total of 53 papers on the effect of fluoride on female reproductive organs, including 6 population surveys were examined. Google Scholar, Google, Research Gate, PubMed, and the International Journal of Fluoride have all been searched for fluoride research papers. Various doses and pathological effects have been described in this review article.

摘要

近年来,人们为研究氟化物对女性生殖器官的影响付出了诸多综合努力。摄入氟化物会对人体健康造成不良影响,如导致氟骨症、氟斑牙、骨折、肾脏问题、出生率下降、甲状腺功能减弱以及智力受损,尤其是对儿童。在这篇综述中,我们讨论了氟化物对女性生殖器官的不良影响并提出了一些补救措施。我们共查阅了53篇关于氟化物对女性生殖器官影响的论文,其中包括6项人口调查。我们检索了谷歌学术、谷歌、研究之门、PubMed以及《国际氟化物杂志》等平台上的氟化物研究论文。这篇综述文章描述了各种剂量及病理效应。

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Biol Trace Elem Res. 2025 Feb;203(2):646-669. doi: 10.1007/s12011-024-04203-7. Epub 2024 May 6.
2
Effects of fluoride toxicity on the male reproductive system: A review.氟中毒对男性生殖系统的影响:综述
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Fluoride-induced testicular and ovarian toxicity: evidence from animal studies.

本文引用的文献

1
A Comparative Analysis of Fluoride-Contaminated Groundwater and Sodium Fluoride-Induced Reproductive Toxicity and Its Reversibility in Male Rats.氟污染地下水与氟化钠诱导雄性大鼠生殖毒性及其可逆性的比较分析。
Biol Trace Elem Res. 2020 Oct;197(2):507-521. doi: 10.1007/s12011-019-01994-y. Epub 2019 Dec 13.
2
Mitochondrial respiratory chain complex abnormal expressions and fusion disorder are involved in fluoride-induced mitochondrial dysfunction in ovarian granulosa cells.线粒体呼吸链复合物异常表达和融合障碍参与氟诱导的卵巢颗粒细胞线粒体功能障碍。
Chemosphere. 2019 Jan;215:619-625. doi: 10.1016/j.chemosphere.2018.10.043. Epub 2018 Oct 8.
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氟化物诱导的睾丸和卵巢毒性:来自动物研究的证据。
Biol Res. 2025 Jan 25;58(1):6. doi: 10.1186/s40659-025-00586-6.
Probabilistic risk assessment of exposure to fluoride in most consumed brands of tea in the Middle East.
中东地区消费最多的茶品牌中氟暴露的概率风险评估。
Food Chem Toxicol. 2018 May;115:267-272. doi: 10.1016/j.fct.2018.03.023. Epub 2018 Mar 19.
4
Sodium fluoride disturbs DNA methylation of NNAT and declines oocyte quality by impairing glucose transport in porcine oocytes.氟化钠会干扰NNAT的DNA甲基化,并通过损害猪卵母细胞中的葡萄糖转运来降低卵母细胞质量。
Environ Mol Mutagen. 2018 Apr;59(3):223-233. doi: 10.1002/em.22165. Epub 2017 Dec 29.
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Health risk assessment to fluoride in drinking water of rural residents living in the Poldasht city, Northwest of Iran.伊朗西北部波尔德沙特市农村居民饮用水中氟化物的健康风险评估。
Ecotoxicol Environ Saf. 2018 Feb;148:426-430. doi: 10.1016/j.ecoenv.2017.10.057. Epub 2017 Nov 6.
6
Interaction of DNA-lesions induced by sodium fluoride and radiation and its influence in apoptotic induction in cancer cell lines.氟化钠与辐射诱导的DNA损伤之间的相互作用及其对癌细胞系凋亡诱导的影响。
Toxicol Rep. 2015 Feb 9;2:461-471. doi: 10.1016/j.toxrep.2015.02.001. eCollection 2015.
7
The MMP-9/TIMP-1 System is Involved in Fluoride-Induced Reproductive Dysfunctions in Female Mice.基质金属蛋白酶-9/金属蛋白酶组织抑制因子-1系统参与氟诱导的雌性小鼠生殖功能障碍。
Biol Trace Elem Res. 2017 Aug;178(2):253-260. doi: 10.1007/s12011-016-0929-3. Epub 2017 Jan 7.
8
Expression and localization of matrix metalloproteinases (MMP-2, -7, -9) and their tissue inhibitors (TIMP-2, -3) in the chicken oviduct during pause in laying induced by tamoxifen.他莫昔芬诱导产蛋暂停期间鸡输卵管中基质金属蛋白酶(MMP - 2、- 7、- 9)及其组织抑制剂(TIMP - 2、- 3)的表达与定位
Theriogenology. 2017 Jan 15;88:50-60. doi: 10.1016/j.theriogenology.2016.09.051. Epub 2016 Oct 6.
9
Fluoride induced endoplasmic reticulum stress and calcium overload in ameloblasts.氟化物诱导成釉细胞内质网应激和钙超载。
Arch Oral Biol. 2016 Sep;69:95-101. doi: 10.1016/j.archoralbio.2016.05.015. Epub 2016 May 26.
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Effect of high-dose fluoride on antioxidant enzyme activities of amniotic Fluid in rats.高剂量氟对大鼠羊水抗氧化酶活性的影响。
J Pak Med Assoc. 2016 Apr;66(4):435-8.