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基于对中国山西省居民的知识、态度和实践(KAP)调查,开发并验证用于预测用药风险的列线图。

Development and validation of a nomogram to predict medication risk based on a knowledge, attitude and practice (KAP) survey of residents in Shanxi Province, China.

作者信息

Xie Da-Shuai, Xie Xue-Hu, Yang Li-Hua, Li Na, Zhang Xiao, Xie Yi-Tong, Yang Wei, Ning Yao-Jun, Xie Jun, Cheng Xiao-Jun, Duan Shao-Jun, Wang Shi-Wei, Hao Li-Hong, Shi Ping

机构信息

Department of Pharmacy, Yuncheng Central Hospital Affiliated to Shanxi Medical University, Yuncheng, China.

National Drug Clinical Trial Institution, Shanxi Province Hospital of Traditional Chinese Medicine, Taiyuan, China.

出版信息

Front Pharmacol. 2024 Apr 17;15:1302274. doi: 10.3389/fphar.2024.1302274. eCollection 2024.

DOI:10.3389/fphar.2024.1302274
PMID:38711987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11070833/
Abstract

OBJECTIVE

Unsafe medication practices and medication errors are a major cause of harm in healthcare systems around the world. This study aimed to explore the factors that influence the risk of medication and provide medication risk evaluation model for adults in Shanxi province, China.

METHODS

The data was obtained from the provincial questionnaire from May to December 2022, relying on the random distribution of questionnaires and online questionnaires by four hospitals in Shanxi Province. Multiple linear regression analysis was used to explore the factors affecting the KAP score of residents. Univariate and multivariate logistic regression was used to determine the independent risk factors, and the nomogram was verified by receiver operating characteristic curve, calibration and decision curve analysis.

RESULTS

A total of 3,388 questionnaires were collected, including 3,272 valid questionnaires. The average scores of drugs KAP were 63.2 ± 23.04, 33.05 ± 9.60, 23.67 ± 6.75 and 33.16 ± 10.87, respectively. On the evaluation criteria of the questionnaire, knowledge was scored "fair", attitude and practice were scored "good". Sex, monthly income, place of residence, insurance status, education level, and employment were regarded as independent risk factors for medication and a nomogram was established by them.

CONCLUSION

Males, low-income, and low-educated people are important factors affecting the risk of medication. The application of the model can help residents understand the risk of their own medication behavior and reduce the harm of medication.

摘要

目的

不安全的用药行为和用药错误是全球医疗系统中伤害的主要原因。本研究旨在探索影响用药风险的因素,并为中国山西省成年人提供用药风险评估模型。

方法

数据来源于2022年5月至12月的省级调查问卷,依托山西省四家医院的问卷随机发放和在线问卷。采用多元线性回归分析探索影响居民KAP得分的因素。单因素和多因素逻辑回归用于确定独立危险因素,并通过受试者工作特征曲线、校准和决策曲线分析对列线图进行验证。

结果

共收集问卷3388份,其中有效问卷3272份。药物KAP平均得分分别为63.2±23.04、33.05±9.60、23.67±6.75和33.16±10.87。按照问卷评估标准,知识得分为“中等”,态度和行为得分为“良好”。将性别、月收入、居住地点、保险状况、教育水平和就业情况视为用药的独立危险因素,并据此建立列线图。

结论

男性、低收入和低教育水平人群是影响用药风险的重要因素。该模型的应用有助于居民了解自身用药行为风险,减少用药危害。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f9/11070833/d1e2526a71a3/fphar-15-1302274-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f9/11070833/bb47b58fbaaf/fphar-15-1302274-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f9/11070833/1948d3ec1a8a/fphar-15-1302274-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f9/11070833/784cc9ba564f/fphar-15-1302274-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f9/11070833/cc8b5e2d5a44/fphar-15-1302274-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f9/11070833/d1e2526a71a3/fphar-15-1302274-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f9/11070833/bb47b58fbaaf/fphar-15-1302274-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f9/11070833/1948d3ec1a8a/fphar-15-1302274-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f9/11070833/784cc9ba564f/fphar-15-1302274-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f9/11070833/cc8b5e2d5a44/fphar-15-1302274-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f9/11070833/d1e2526a71a3/fphar-15-1302274-g005.jpg

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