Real-time expert-system-based fuzzy control of mean arterial pressure in pigs with sodium nitroprusside infusion.

This paper deals with real-time fuzzy control of mean arterial pressure (MAP) in pigs by regulating the infusion rate of the vasodilator drug, sodium nitroprusside (SNP). The fuzzy controller was based on the parallel firing mode of a general-purpose Fuzzy LOgic Production System shell, FLOPS [2,3,16,20]. One of the major advantages of this fuzzy control drug delivery system over other existing automatic drug delivery systems is that the fuzzy control system may be designed by using experts' knowledge and experience without any explicit mathematical models involved. Mean arterial pressure in pigs was controlled satisfactorily in real-time by the fuzzy control system. It comes to the conclusion that it may be feasible to employ this fuzzy controller in the management of mean arterial pressure of patients clinically. Also, various applications of the fuzzy controller may exist in industry and in biomedical engineering.