Meline L J, Westenskow D R, Pace N L, Bodily M N
Anesth Analg. 1985 Jan;64(1):38-42.
We built and tested a combined proportional/derivative and minimum variance adaptive control algorithm for the regulation of blood pressure using sodium nitroprusside (SNP). In ten dogs the pressure was reduced by 30 mm Hg for 1 hr. The blood pressure came to within 5 mm Hg of the desired pressure in 1.7 +/- 4 min and after 3.4 +/- 0.3 min it remained within +/- 5 mm Hg of the desired value. During the nitroprusside infusion, bolus doses of epinephrine and SNP as well as phlebotomy were used to challenge the controller. The controller responded rapidly and effectively so that blood pressure remained stable throughout each challenge. Control was achieved in ten dogs with very different sensitivities to SNP. After 1 hr of SNP infusion, the rate of SNP infusion required to maintain a 30 mm Hg reduction in pressure averaged 112 ml/hr with a standard deviation of 108 ml/hr. Adaptive control met the challenge of large differences in sensitivity and maintained the desired blood pressure.
我们构建并测试了一种比例/微分与最小方差相结合的自适应控制算法，用于使用硝普钠（SNP）调节血压。在10只狗身上，血压降低30毫米汞柱并持续1小时。血压在1.7±4分钟内达到距期望血压5毫米汞柱以内，3.4±0.3分钟后保持在距期望值±5毫米汞柱以内。在硝普钠输注期间，使用肾上腺素和硝普钠的推注剂量以及放血来挑战控制器。控制器反应迅速且有效，使得在每次挑战过程中血压都保持稳定。在对SNP敏感性差异很大的10只狗中实现了控制。在输注SNP 1小时后，维持血压降低30毫米汞柱所需的SNP输注速率平均为112毫升/小时，标准差为108毫升/小时。自适应控制应对了敏感性的巨大差异挑战，并维持了期望的血压。
