Lachant N A, Sun N C, Leong L A, Oseas R S, Prince H E
Am J Clin Pathol. 1985 Jan;83(1):27-33. doi: 10.1093/ajcp/83.1.27.
Two homosexual men with the acquired immunodeficiency syndrome (AIDS) who developed a multicentric variant of angiofollicular lymph node hyperplasia (AFLNH) (Castleman's disease) and Kaposi's sarcoma are reported. Both had diffuse adenopathy, splenomegaly, and a systemic inflammatory state. Both had an absolute increase in Leu 1+ lymphocytes, which was associated with markedly decreased Leu 3+ lymphocytes, markedly increased Leu-2+ lymphocytes, and a very low Leu 3/2 ratio. The lymphocytes of both patients had a normal blastogenic response to PHA. The lymphocytes of patient 1 had a poor response to autologous or allogenic cells in the mixed lymphocyte culture reaction. AFLNH represents another lymphoreticular complication of AIDS. Given the interrelationships between AFLNH, the development of Kaposi's sarcoma, and the aggressive clinical course seen in our two patients and those in the literature, the aggressive use of lymph node biopsy may be an important prognostic tool for the patient with the acquired immunodeficiency syndrome.
报告了两名患有获得性免疫缺陷综合征（AIDS）的同性恋男性，他们发生了血管滤泡性淋巴结增生（AFLNH）（卡斯尔曼病）的多中心型和卡波西肉瘤。两人均有弥漫性淋巴结病、脾肿大和全身炎症状态。两人的Leu 1+淋巴细胞绝对数增加，这与Leu 3+淋巴细胞明显减少、Leu -2+淋巴细胞明显增加以及极低的Leu 3/2比值相关。两名患者的淋巴细胞对PHA的增殖反应正常。在混合淋巴细胞培养反应中，患者1的淋巴细胞对自体或同种异体细胞反应较差。AFLNH是AIDS的另一种淋巴网状并发症。鉴于AFLNH、卡波西肉瘤的发生以及我们两名患者和文献中所见的侵袭性临床病程之间的相互关系，积极进行淋巴结活检可能是获得性免疫缺陷综合征患者的一项重要预后工具。
