Stowers Institute for Medical Research, Kansas City, MO 64110.
Proc Natl Acad Sci U S A. 2024 May 14;121(20):e2321919121. doi: 10.1073/pnas.2321919121. Epub 2024 May 7.
Successful regeneration of missing tissues requires seamless integration of positional information along the body axes. Planarians, which regenerate from almost any injury, use conserved, developmentally important signaling pathways to pattern the body axes. However, the molecular mechanisms which facilitate cross talk between these signaling pathways to integrate positional information remain poorly understood. Here, we report a () which functionally integrates the anterior-posterior (AP) and the medio-lateral (ML) axes. inhibits WNT/β-catenin signaling along the AP axis and, functions synergistically with the β-catenin-independent WNT signaling of the ML axis. Furthermore, this functional integration is dependent on and -the components of the Hippo/Yorkie (YKI) pathway. Hippo/YKI pathway is a critical regulator of body size in flies and mice, but our data suggest the pathway regulates body axes patterning in planarians. Our study provides a signaling network integrating positional information which can mediate coordinated growth and patterning during planarian regeneration.
成功的组织再生需要沿身体轴的位置信息的无缝整合。再生能力极强的水螅，利用保守的、发育上重要的信号通路来塑造身体轴。然而，促进这些信号通路之间的串扰以整合位置信息的分子机制仍知之甚少。在这里，我们报告了一个 ()，它在功能上整合了前后 (AP) 和中侧 (ML) 轴。 抑制 AP 轴上的 WNT/β-catenin 信号通路，并且与 ML 轴上的β-catenin 非依赖性 WNT 信号通路协同作用。此外，这种功能整合依赖于 Hippo/Yorkie (YKI) 途径的 和 -成分。Hippo/YKI 途径是果蝇和小鼠体型的关键调节剂，但我们的数据表明该途径调节水螅的身体轴模式形成。我们的研究提供了一个整合位置信息的信号网络，该网络可以在水螅再生过程中介导协调的生长和模式形成。
