College of Science, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Colloids Surf B Biointerfaces. 2024 Jul;239:113911. doi: 10.1016/j.colsurfb.2024.113911. Epub 2024 Apr 10.
An innovative nanozyme, iron-doped polydopamine (Fe-PDA), which integrates iron ions into a PDA matrix, conferred peroxidase-mimetic activity and achieved a substantial photothermal conversion efficiency of 43.5 %. Fe-PDA mediated the catalysis of HO to produce toxic hydroxyl radicals (•OH), thereby facilitating lipid peroxidation in tumour cells and inducing ferroptosis. Downregulation of solute carrier family 7 no. 11 (SLC7A11) and solute carrier family 3 no. 2 (SLC3A2) in System Xc- resulted in decreased intracellular glutathione (GSH) production and inactivation of the nuclear factor erythroid 2-related factor 2 (NRF2)-glutathione peroxidase 4 (GPX4) pathway, contributing to ferroptosis. Moreover, the application of photothermal therapy (PTT) enhanced the effectiveness of chemodynamic therapy (CDT), accelerating the Fenton reaction for targeted tumour eradication while sparing adjacent non-cancerous tissues. In vivo experiments revealed that Fe-PDA significantly hampered tumour progression in mice, emphasizing the potential of the dual-modality treatment combining CDT and PTT for future clinical oncology applications.
一种创新的纳米酶，即铁掺杂的聚多巴胺（Fe-PDA），将铁离子整合到 PDA 基质中，赋予其过氧化物酶模拟活性，并实现了 43.5%的显著光热转换效率。Fe-PDA 介导 HO 的催化产生有毒的羟基自由基（•OH），从而促进肿瘤细胞中的脂质过氧化和诱导铁死亡。System Xc- 中溶质载体家族 7 成员 11（SLC7A11）和溶质载体家族 3 成员 2（SLC3A2）的下调导致细胞内谷胱甘肽（GSH）生成减少和核因子红细胞 2 相关因子 2（NRF2）-谷胱甘肽过氧化物酶 4（GPX4）途径失活，导致铁死亡。此外，光热治疗（PTT）的应用增强了化学动力学治疗（CDT）的效果，加速了芬顿反应，以靶向肿瘤消除，同时保护相邻的非癌组织。体内实验表明，Fe-PDA 显著抑制了小鼠的肿瘤进展，强调了将 CDT 和 PTT 相结合的双重模式治疗在未来临床肿瘤学中的应用潜力。
