超高压和多维液相色谱仪器及工作流程的进展。

Advances in ultra-high-pressure and multi-dimensional liquid chromatography instrumentation and workflows.

作者信息

De Vos Jelle, Stoll Dwight, Buckenmaier Stephan, Eeltink Sebastiaan, Grinias James P

机构信息

Department of Chemical Engineering Vrije Universiteit Brussel (VUB) Brussels Belgium.

Department of Chemistry Gustavus Aldophus College Saint Peter Minnesota USA.

出版信息

Anal Sci Adv. 2021 Mar 16;2(3-4):171-192. doi: 10.1002/ansa.202100007. eCollection 2021 Apr.

The present contribution discusses recent advances in ultra-high-pressure liquid chromatography (UHPLC) and multi-dimensional liquid chromatography (MDLC) technology. First, new developments in UHPLC column technology and system design are highlighted. The latter includes a description of a novel injector concept enabling method speed-up, emerging detectors, and instrument diagnostics approaches. Next, online MDLC workflows are reviewed and advances in modulation technology are highlighted. Finally, key applications published in 2020 are reviewed.