The Seventh People's Hospital of Chongqing, No. 1, Village 1, Lijiatuo Labor Union, Banan District, Chongqing, China.
J Int Med Res. 2024 May;52(5):3000605241247707. doi: 10.1177/03000605241247707.
Lipopolysaccharide (LPS) is widely used to establish various animal models, including models of acute lung injury, cardiomyocyte damage, and acute kidney injury. Currently, there is no consensus on the diagnosis and treatment of LPS-induced disease. We herein present a case series of four patients who developed dose-dependent multi-organ injury, including acute lung injury and acute kidney injury, after inhaling LPS gas in a sealed room. These patients exhibited varying degrees of multi-organ injury characterized by inflammatory cell infiltration and secretion of proinflammatory cytokines. One patient showed progressive symptoms even with active treatment, leading to mild pulmonary fibrosis. This study emphasizes the importance of early diagnosis and treatment of significant LPS exposure and suggests personalized treatment approaches for managing LPS poisoning.
脂多糖（LPS）被广泛用于建立各种动物模型，包括急性肺损伤、心肌细胞损伤和急性肾损伤模型。目前，对于 LPS 诱导疾病的诊断和治疗尚无共识。我们在此报告了 4 例患者的病例系列，这些患者在密封的房间内吸入 LPS 气体后，出现了剂量依赖性的多器官损伤，包括急性肺损伤和急性肾损伤。这些患者表现出不同程度的多器官损伤，特征为炎症细胞浸润和促炎细胞因子的分泌。有 1 例患者即使进行了积极治疗，症状仍逐渐加重，导致轻度肺纤维化。本研究强调了早期诊断和治疗大量 LPS 暴露的重要性，并建议采用个体化治疗方法来管理 LPS 中毒。
