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Radiation-induced crosslinks between thymine and phenylalanine.

作者信息

Dizdaroglu M, Simic M G

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1985 Jan;47(1):63-9. doi: 10.1080/09553008514550091.

DOI:10.1080/09553008514550091
PMID:3871746
Abstract

OH radicals generated by ionizing radiation in aqueous solutions of thymine (T) and phenylalanine (Phe) induce crosslinking between thymine and phenylalanine. The crosslinked products were isolated and characterized by capillary gas chromatography-mass spectrometry. They are formed via OH radical adducts to thymine and phenylalanine and the reaction between dissimilar radicals is greatly favoured (T-Phe:Phe-Phe:T-T = 0.46:0.14:0.05). The reaction mechanism presented may serve as a model for radiation or any free radical-induced crosslinks between DNA and proteins.

摘要

相似文献

1
Radiation-induced crosslinks between thymine and phenylalanine.
Int J Radiat Biol Relat Stud Phys Chem Med. 1985 Jan;47(1):63-9. doi: 10.1080/09553008514550091.
2
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引用本文的文献

1
Protein-DNA crosslinking in reconstituted nucleohistone, nuclei and whole cells by picosecond UV laser irradiation.通过皮秒紫外激光照射在重组核组蛋白、细胞核和全细胞中进行蛋白质-DNA交联。
Nucleic Acids Res. 1988 May 25;16(10):4525-38. doi: 10.1093/nar/16.10.4525.