Department of Surgery, Yale School of Medicine, New Haven, CT, USA.
Yale National Clinician Scholars Program, New Haven, CT, USA.
Ann Surg Oncol. 2024 Aug;31(8):5168-5179. doi: 10.1245/s10434-024-15360-3. Epub 2024 May 8.
Many women eligible for breast conservation therapy (BCT) elect unilateral mastectomy (UM) with or without contralateral prophylactic mastectomy (CPM) and cite a desire for "peace of mind." This study aimed to characterize how peace of mind is defined and measured and how it relates to surgical choice.
Nine databases were searched for relevant articles through 8 October 2023, and data were extracted from articles meeting the inclusion criteria.
The inclusion criteria were met by 20 studies. Most were prospective cohort studies (65%, 13/20). In the majority of the studies (72%, 13/18), Non-Hispanic white/Caucasian women comprised 80 % or more of the study's sample. Almost half of the studies used the phrase "peace of mind" in their publication (45%, 9/20), and few directly defined the construct (15%, 3/20). Instead, words representing an absence of peace of mind were common, specifically, "anxiety" (85%, 17/20), "fear" (75%, 15/20), and "concern" (75%, 15/20). Most of the studies (90%, 18/20) measured peace of mind indirectly using questionnaires validated for anxiety, fear, worry, distress, or concern, which were administered at multiple postoperative time points (55%, 11/20). Most of the studies (95%, 18/19) reported at least one statistically significant result showing no difference in peace of mind between BCT, UM, and/or CPM at their latest time of assessment.
Peace of mind is largely framed around concepts that suggest its absence, namely, anxiety, fear, and concern. Existing literature suggests that peace of mind does not differ among average-risk women undergoing BCT, UM, or CPM. Shared surgical decisions should emphasize at least comparable emotional and/or psychosocial well-being between CPM and breast conservation.
许多有资格接受保乳治疗(BCT)的女性选择单侧乳房切除术(UM),并伴有或不伴有对侧预防性乳房切除术(CPM),并表示希望“安心”。本研究旨在描述“安心”的定义和测量方法,以及它与手术选择的关系。
通过 2023 年 8 月 8 日检索了 9 个数据库中的相关文章,并从符合纳入标准的文章中提取数据。
符合纳入标准的研究有 20 项。其中大多数为前瞻性队列研究(65%,13/20)。在大多数研究中(72%,13/18),研究样本中 80%或以上为非西班牙裔白人/白种人。近一半的研究(45%,9/20)在出版物中使用了“安心”一词,很少有研究直接定义该结构(15%,3/20)。相反,代表缺乏安心的词语很常见,具体来说,“焦虑”(85%,17/20)、“恐惧”(75%,15/20)和“担忧”(75%,15/20)。大多数研究(90%,18/20)通过问卷调查间接测量安心,这些问卷是针对焦虑、恐惧、担忧、痛苦或关注等方面进行验证的,并在多个术后时间点进行评估(55%,11/20)。大多数研究(95%,18/19)报告了至少一个具有统计学意义的结果,表明在最新评估时间点,BCT、UM 和/或 CPM 之间的安心程度没有差异。
安心主要围绕着暗示其缺失的概念,即焦虑、恐惧和担忧。现有文献表明,在接受 BCT、UM 或 CPM 的平均风险女性中,安心程度没有差异。共同的手术决策应至少强调 CPM 和保乳之间情绪和/或社会心理幸福感的可比性。