有抑郁症状的成年人使用膳食补充剂的几率较低。

Adults with depressive symptoms have lower odds of dietary supplement use.

机构信息

Interventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada.

Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

出版信息

PLoS One. 2024 May 8;19(5):e0302637. doi: 10.1371/journal.pone.0302637. eCollection 2024.

DOI:10.1371/journal.pone.0302637

PMID:38718014

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11078386/

Abstract

OBJECTIVE

In this study, we aim to evaluate dietary supplement and complementary and alternative medicine (CAM) use in individuals with depressive symptoms. Furthermore, we conducted a comparative analysis of the usage of these agents among individuals with depressive symptoms, differentiating between those who were using antidepressants and those who were not. Additionally, we compared individuals with depressive symptoms who were not using antidepressants with participants who did not have depressive symptoms as well as individuals with depressive symptoms who were using antidepressants with individuals without depressive symptoms.

METHOD

The National Health and Nutrition Examination Survey 2007-2018 data was collected. Depressive symptoms were assessed using patient health questionnaire-9. Dietary supplement and antidepressants use was evaluated using Dietary Supplement Use and Prescription Medications Questionnaires.

RESULTS

31,445 participants, with 2870 (8.05%) having depressive symptoms were included. Participants with depressive symptoms had significantly lower odds of dietary supplement use compared with those without depressive symptoms (aOR = 0.827, 95% CI: 0.700,0.977, p = 0.026). Participants with depressive symptoms who were using antidepressants had significantly higher odds of dietary supplement (aOR = 1.290, 95% CI: 1.038,1.604, p = 0.022) compared with participants with depressive symptoms who were not using antidepressants. Furthermore, Participants with depressive symptoms who weren't using antidepressants had significantly lower odds of dietary supplement use (aOR = 0.762, 95% CI: 0.632,0.918, p = 0.005) compared with participants without depressive symptoms. In individuals with treated depressive symptoms compared to those without depressive symptoms, CAM use was significantly lower (aOR = 0.763, 95% CI = 0.598,0.973, p = 0.030).

CONCLUSION

Individuals with depressive symptoms have lower odds of dietary supplement use. Further studies are needed to replicate these findings and examine the underlying mechanisms for this association.

摘要

目的

本研究旨在评估有抑郁症状个体的膳食补充剂和补充与替代医学（CAM）使用情况。此外，我们对使用这些药物的抑郁症状患者进行了比较分析，区分了使用抗抑郁药和未使用抗抑郁药的患者。此外，我们还将未使用抗抑郁药的抑郁症状患者与无抑郁症状的参与者以及使用抗抑郁药的抑郁症状患者与无抑郁症状的患者进行了比较。

方法

我们收集了 2007-2018 年国家健康和营养检查调查的数据。使用患者健康问卷-9 评估抑郁症状。使用膳食补充剂使用和处方药问卷评估膳食补充剂和抗抑郁药的使用情况。

结果

共纳入 31445 名参与者，其中 2870 名（8.05%）有抑郁症状。有抑郁症状的参与者使用膳食补充剂的可能性明显低于无抑郁症状的参与者（调整后的优势比[aOR]=0.827，95%置信区间[CI]：0.700，0.977，p=0.026）。使用抗抑郁药的有抑郁症状的参与者使用膳食补充剂的可能性明显高于未使用抗抑郁药的有抑郁症状的参与者（aOR=1.290，95%CI：1.038，1.604，p=0.022）。此外，未使用抗抑郁药的有抑郁症状的参与者使用膳食补充剂的可能性明显低于无抑郁症状的参与者（aOR=0.762，95%CI：0.632，0.918，p=0.005）。与无抑郁症状的个体相比，接受治疗的抑郁症状患者 CAM 的使用明显更低（aOR=0.763，95%CI=0.598，0.973，p=0.030）。