通过多种免疫刺激剂的协同作用在正常小鼠中诱导严重自身免疫性疾病。
Induction of severe autoimmune disease in normal mice by simultaneous action of multiple immunostimulators.
作者信息
Hang L M, Aguado M T, Dixon F J, Theofilopoulos A N
出版信息
J Exp Med. 1985 Feb 1;161(2):423-8. doi: 10.1084/jem.161.2.423.
Abstract
Either of two immunostimulating factors (lpr, lipopolysaccharide) enhanced the pathogenic autoimmune responses of MRL/n mice, but the serologic and immunopathologic characteristics differed. In contrast, either factor acting alone, caused minimal immunopathology in normal mice, despite autoantibody induction. Combined immunostimulation, however, caused fatal glomerulonephritis in normal-background C57BL/6 mice. These results show the profound influence of the background genome on the effects of immunostimulating agents, and show that resistance to autoimmune disease in immunologically normal mice is not absolute.
摘要
两种免疫刺激因子（lpr，脂多糖）中的任何一种都会增强MRL/n小鼠的致病性自身免疫反应，但血清学和免疫病理学特征有所不同。相比之下，尽管会诱导自身抗体产生，但这两种因子单独作用于正常小鼠时，只会引起轻微的免疫病理学变化。然而，联合免疫刺激会在正常背景的C57BL/6小鼠中引发致命的肾小球肾炎。这些结果表明背景基因组对免疫刺激剂的作用有深远影响，并且表明免疫正常小鼠对自身免疫性疾病的抵抗力并非绝对。
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