Hang L, Theofilopoulos A N, Dixon F J
J Exp Med. 1982 Jun 1;155(6):1690-701. doi: 10.1084/jem.155.6.1690.
MRL/l mice spontaneously develop an arthritis very similar in many respects to human rheumatoid arthritis. A detailed morphologic and serologic analysis of this disease revealed the following: (a) a 75% incidence of synovial and periarticular inflammation, very similar to human rheumatoid arthritis, in 5-6 mo-old females, (b) close associations between presence of joint inflammation and subsynovial and/or periarticular vasculitis, and (c) a close correlation between presence of circulating IgM rheumatoid factor (RF) and demonstrable synovial and/or joint pathology, i.e., 95% of mice with significant levels of IgMRF had synovitis and/or arthritis.
MRL/l小鼠会自发发展出一种在许多方面与人类类风湿性关节炎非常相似的关节炎。对这种疾病进行的详细形态学和血清学分析揭示了以下几点：(a) 在5-6月龄的雌性小鼠中，滑膜和关节周围炎症的发生率为75%，与人类类风湿性关节炎非常相似；(b) 关节炎症的存在与滑膜下和/或关节周围血管炎密切相关；(c) 循环IgM类风湿因子（RF）的存在与可证实的滑膜和/或关节病理密切相关，即95% IgM RF水平显著的小鼠患有滑膜炎和/或关节炎。
