Pasto M E, Graziani L J, Tunis S L, Deiling J M, Kurtz A B, Goldberg B, Finnegan L P
Pediatr Radiol. 1985;15(2):77-81. doi: 10.1007/BF02388706.
Cranial ultrasound examinations were performed during the first 3 days of life and at age 1 month on 22 infants with the neonatal abstinence syndrome. The results were compared to those obtained in 15 control infants who were not exposed to narcotic drugs in utero. The ultrasound images were examined for ventricular configuration, intracranial hemidiameters, area of thalami, and width of temporal lobes. At 24 to 72 h and at 1 month of age, significantly more drug-exposed than control infants had a slit-like ventricular configuration. The intracranial hemidiameter was significantly smaller in the drug-exposed than in the control infants. All cerebral measurements except the right temporal lobe demonstrated significant growth over the first month of life in both groups of infants. By means of ancillary examinations (computerized tomography and transfontanel pressure measurements) the pathogenesis of the slit-like ventricles was found not to be related to edema or to increased intracranial pressure. Whether or not the ventricles remain small and brain growth remains parallel after the period of abstinence awaits further investigation.
对22例患有新生儿戒断综合征的婴儿在出生后的前3天及1月龄时进行了头颅超声检查。将检查结果与15例未在子宫内接触过麻醉药物的对照婴儿的结果进行比较。对超声图像检查了脑室形态、颅内半径、丘脑面积和颞叶宽度。在24至72小时以及1月龄时，接触药物的婴儿出现裂隙状脑室形态的比例显著高于对照婴儿。接触药物的婴儿的颅内半径明显小于对照婴儿。两组婴儿在出生后的第一个月内，除右侧颞叶外，所有脑部测量指标均显示出显著增长。通过辅助检查（计算机断层扫描和经囟门压力测量）发现，裂隙状脑室的发病机制与水肿或颅内压升高无关。戒断期过后脑室是否仍保持狭小以及脑生长是否仍保持平行，有待进一步研究。
