Chasnoff I J, Hatcher R, Burns W J
Am J Dis Child. 1980 Nov;134(11):1049-51. doi: 10.1001/archpedi.1980.02130230029009.
The early growth patterns of 15 full-term infants born to mothers on well-controlled, low-dose methadone hydrochloride maintenance were studied. Mean birth weight and length were at the tenth percentile, and mean head circumference was at the fifth percentile. Early withdrawal symptoms persisted for three to four months, and mean growth parameters continued along their respective percentiles. As withdrawal symptoms abated at 4 to 6 months, infants became more responsive, easier to handle, and demonstrated an accelerated growth pattern. This acceleration of growth at 4 to 6 months of age corresponded to patterns found in previous animal studies.
对15名母亲在服用剂量控制良好的低剂量盐酸美沙酮维持治疗期间所生的足月婴儿的早期生长模式进行了研究。平均出生体重和身长处于第十百分位，平均头围处于第五百分位。早期戒断症状持续三到四个月，平均生长参数继续沿着各自的百分位发展。随着4至6个月时戒断症状减轻，婴儿反应性更强，更易于照料，并呈现出加速生长模式。这种4至6个月龄时的生长加速与先前动物研究中发现的模式相符。
