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一名因混合性结缔组织病（MCTD）接受免疫抑制治疗的患者出现播散性组织胞浆菌病伴脂膜炎和巨噬细胞活化综合征。

Disseminated Histoplasmosis Presenting with Panniculitis and Macrophage Activation Syndrome in a Patient Undergoing Immunosuppressive Therapy for Mixed Connective Tissue Disease (MCTD).

作者信息

Kawashima Hirotoshi, Saku Aiko, Konishi Mai, Hayashi Yuichiro, Watanabe Akira, Hirose Koichi

机构信息

Department of Rheumatology, School of Medicine, International University of Health and Welfare, Japan.

Department of Pathology, International University of Health and Welfare Narita Hospital, Japan.

出版信息

Intern Med. 2025 Jan 1;64(1):141-146. doi: 10.2169/internalmedicine.3597-24. Epub 2024 May 9.

DOI:10.2169/internalmedicine.3597-24
PMID:38719595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11781929/
Abstract

Histoplasmosis, a fungal infection caused by Histoplasma capsulatum, is endemic in many parts of the world. However, this is not common in Japan. We herein present a unique case of military histoplasmosis in a 45-year-old female with mixed connective tissue disease (MCTD) who was receiving immunosuppressive therapy. The histological findings coupled with molecular confirmation led to final a diagnosis. This case emphasizes the diagnostic challenges associated with histoplasmosis in immunocompromised patients and underscores the importance of considering it in the differential diagnosis of any atypical presentation in rheumatic patients.

摘要

组织胞浆菌病是由荚膜组织胞浆菌引起的真菌感染，在世界许多地区呈地方性流行。然而，在日本并不常见。我们在此报告一例独特的粟粒性组织胞浆菌病病例，患者为一名45岁患有混合性结缔组织病（MCTD）且正在接受免疫抑制治疗的女性。组织学检查结果结合分子学确认得出了最终诊断。该病例强调了免疫功能低下患者中组织胞浆菌病相关的诊断挑战，并突出了在风湿性疾病患者任何非典型表现的鉴别诊断中考虑该病的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52af/11781929/f5e1efce1105/1349-7235-64-0141-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52af/11781929/ebfa4cfa4bc4/1349-7235-64-0141-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52af/11781929/5166116289ac/1349-7235-64-0141-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52af/11781929/76265be9b7ac/1349-7235-64-0141-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52af/11781929/f5e1efce1105/1349-7235-64-0141-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52af/11781929/ebfa4cfa4bc4/1349-7235-64-0141-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52af/11781929/5166116289ac/1349-7235-64-0141-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52af/11781929/76265be9b7ac/1349-7235-64-0141-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52af/11781929/f5e1efce1105/1349-7235-64-0141-g004.jpg

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J Fungi (Basel). 2022 Apr 23;8(5):438. doi: 10.3390/jof8050438.
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Timely Diagnosis of Histoplasmosis in Non-endemic Countries: A Laboratory Challenge.非流行国家组织胞浆菌病的及时诊断：一项实验室挑战。
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Clinical Perspectives in the Diagnosis and Management of Histoplasmosis.组织胞浆菌病诊断与管理的临床视角
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Histoplasmosis.组织胞浆菌病
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