• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种酶联免疫吸附测定法的验证，该方法用于检测哥伦比亚艾滋病患者尿液中的荚膜组织胞浆菌抗原，以用于诊断及治疗期间的随访。

Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in Colombian patients with AIDS for diagnosis and follow-up during therapy.

作者信息

Caceres Diego H, Scheel Christina M, Tobón Angela M, Ahlquist Cleveland Angela, Restrepo Angela, Brandt Mary E, Chiller Tom, Gómez Beatriz L

机构信息

Corporación para Investigaciones Biológicas (CIB), Medical and Experimental Mycology Group, Medellín, Colombia.

Centers for Disease Control and Prevention, Mycotic Diseases Branch, Atlanta, Georgia, USA.

出版信息

Clin Vaccine Immunol. 2014 Sep;21(9):1364-8. doi: 10.1128/CVI.00101-14. Epub 2014 Jul 9.

DOI:10.1128/CVI.00101-14
PMID:25008902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4178582/
Abstract

We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86%, and the overall specificity was 94%. The antigen test successfully monitored the response to therapy.

摘要

我们在患有艾滋病且确诊为组织胞浆菌病的哥伦比亚人中验证了一种抗原捕获酶联免疫吸附测定（ELISA），并评估了随访期间尿抗原与临床改善之间的相关性。荚膜组织胞浆菌ELISA的敏感性为86%，总体特异性为94%。抗原检测成功监测了治疗反应。

相似文献

1
Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in Colombian patients with AIDS for diagnosis and follow-up during therapy.一种酶联免疫吸附测定法的验证，该方法用于检测哥伦比亚艾滋病患者尿液中的荚膜组织胞浆菌抗原，以用于诊断及治疗期间的随访。
Clin Vaccine Immunol. 2014 Sep;21(9):1364-8. doi: 10.1128/CVI.00101-14. Epub 2014 Jul 9.
2
Multicenter Validation of Commercial Antigenuria Reagents To Diagnose Progressive Disseminated Histoplasmosis in People Living with HIV/AIDS in Two Latin American Countries.多中心验证商用抗原尿试剂诊断拉丁美洲两个国家 HIV/AIDS 患者进行性播散性组织胞浆菌病。
J Clin Microbiol. 2018 May 25;56(6). doi: 10.1128/JCM.01959-17. Print 2018 Jun.
3
Detection of the 70-kilodalton histoplasma capsulatum antigen in serum of histoplasmosis patients: correlation between antigenemia and therapy during follow-up.组织胞浆菌病患者血清中70千道尔顿荚膜组织胞浆菌抗原的检测：随访期间抗原血症与治疗的相关性
J Clin Microbiol. 1999 Mar;37(3):675-80. doi: 10.1128/JCM.37.3.675-680.1999.
4
Development and evaluation of an enzyme-linked immunosorbent assay to detect Histoplasma capsulatum antigenuria in immunocompromised patients.用于检测免疫功能低下患者荚膜组织胞浆菌抗原尿的酶联免疫吸附测定法的开发与评估
Clin Vaccine Immunol. 2009 Jun;16(6):852-8. doi: 10.1128/CVI.00066-09. Epub 2009 Apr 8.
5
Evaluation of the IMMY ALPHA Histoplasma antigen enzyme immunoassay for diagnosis of histoplasmosis marked by antigenuria.评估IMMY ALPHA组织胞浆菌抗原酶免疫测定法用于诊断以尿中出现抗原为特征的组织胞浆菌病。
Clin Vaccine Immunol. 2007 Jun;14(6):802-3. doi: 10.1128/CVI.00035-07. Epub 2007 Apr 4.
6
A complementary tool for management of disseminated Histoplasma capsulatum var. capsulatum infections in AIDS patients.一种用于管理艾滋病患者播散性荚膜组织胞浆菌荚膜变种感染的辅助工具。
Int J Med Microbiol. 2014 Nov;304(8):1062-5. doi: 10.1016/j.ijmm.2014.07.016. Epub 2014 Aug 7.
7
The Histoplasma capsulatum antigen assay in disseminated histoplasmosis in children.儿童播散性组织胞浆菌病中的荚膜组织胞浆菌抗原检测
Pediatr Infect Dis J. 1994 Sep;13(9):801-5. doi: 10.1097/00006454-199409000-00010.
8
Evaluation of an enzyme immunoassay for detection of Histoplasma capsulatum antigen from urine specimens.尿液标本中荚膜组织胞浆菌抗原酶免疫测定法的评价。
J Clin Microbiol. 2013 Nov;51(11):3555-9. doi: 10.1128/JCM.01868-13. Epub 2013 Aug 21.
9
Diagnosis of disseminated histoplasmosis by detection of Histoplasma capsulatum antigen in serum and urine specimens.通过检测血清和尿液标本中的荚膜组织胞浆菌抗原诊断播散性组织胞浆菌病。
N Engl J Med. 1986 Jan 9;314(2):83-8. doi: 10.1056/NEJM198601093140205.
10
Clinical evaluation of urine Histoplasma capsulatum antigen measurement in cats with suspected disseminated histoplasmosis.对疑似播散性组织胞浆菌病猫进行尿荚膜组织胞浆菌抗原检测的临床评估。
J Feline Med Surg. 2012 Aug;14(8):512-5. doi: 10.1177/1098612X12450121. Epub 2012 May 24.

引用本文的文献

1
Disseminated Histoplasmosis in Persons Living with HIV, France and Overseas Territories,1992-2021.1992年至2021年法国及海外领地艾滋病病毒感染者中的播散性组织胞浆菌病
Emerg Infect Dis. 2025 Jul;31(7):1377-1385. doi: 10.3201/eid3107.241931.
2
Histoplasma capsulatum urinary antigen detection in a kidney transplant recipient with acute paracoccidioidomycosis: Case study and literature review.荚膜组织胞浆菌尿抗原检测在急性副球孢子菌病肾移植受者中的应用：病例研究及文献复习。
PLoS Negl Trop Dis. 2024 Aug 29;18(8):e0012472. doi: 10.1371/journal.pntd.0012472. eCollection 2024 Aug.
3
Rapid CD4 cell count determination and and antigen detection in people living with HIV: Implementation of a package of care strategy in a pilot study, Argentina.快速测定艾滋病毒感染者的CD4细胞计数及抗原检测：在阿根廷的一项试点研究中实施一整套护理策略
IJID Reg. 2024 Jul 8;12:100403. doi: 10.1016/j.ijregi.2024.100403. eCollection 2024 Sep.
4
Disseminated Histoplasmosis Presenting with Panniculitis and Macrophage Activation Syndrome in a Patient Undergoing Immunosuppressive Therapy for Mixed Connective Tissue Disease (MCTD).一名因混合性结缔组织病（MCTD）接受免疫抑制治疗的患者出现播散性组织胞浆菌病伴脂膜炎和巨噬细胞活化综合征。
Intern Med. 2025 Jan 1;64(1):141-146. doi: 10.2169/internalmedicine.3597-24. Epub 2024 May 9.
5
Diagnostic accuracy of a novel lateral flow assay for histoplasmosis.新型侧流免疫层析法诊断组织胞浆菌病的准确性。
Med Mycol. 2024 Jul 4;62(7). doi: 10.1093/mmy/myae051.
6
Application of Real-Time PCR Assays for the Diagnosis of Histoplasmosis in Human FFPE Tissues Using Three Molecular Targets.实时荧光定量聚合酶链反应检测法在利用三种分子靶点诊断人福尔马林固定石蜡包埋组织中的组织胞浆菌病中的应用
J Fungi (Basel). 2023 Jun 25;9(7):700. doi: 10.3390/jof9070700.
7
Fungal Pathogens as Causes of Acute Respiratory Illness in Hospitalized Veterans: Frequency of Fungal Positive Test Results Using Rapid Immunodiagnostic Assays.真菌病原体作为住院退伍军人急性呼吸道疾病的病因：使用快速免疫诊断检测方法真菌检测呈阳性结果的频率
J Fungi (Basel). 2023 Apr 8;9(4):456. doi: 10.3390/jof9040456.
8
Immunologic Diagnosis of Endemic Mycoses.地方性真菌病的免疫学诊断
J Fungi (Basel). 2022 Sep 22;8(10):993. doi: 10.3390/jof8100993.
9
Validation and Concordance Analysis of a New Lateral Flow Assay for Detection of Antigen in Urine.一种用于检测尿液中抗原的新型侧向流动分析方法的验证与一致性分析
J Fungi (Basel). 2021 Sep 24;7(10):799. doi: 10.3390/jof7100799.
10
Diagnosis of fungal opportunistic infections in people living with HIV from Guatemala and El Salvador.诊断在危地马拉和萨尔瓦多的艾滋病毒感染者中的真菌性机会感染。
Mycoses. 2021 Dec;64(12):1563-1570. doi: 10.1111/myc.13368. Epub 2021 Sep 29.

本文引用的文献

1
Disseminated histoplasmosis in HIV-infected patients in South America: a neglected killer continues on its rampage.南美洲HIV感染患者中的播散性组织胞浆菌病：一种被忽视的杀手仍在肆虐。
PLoS Negl Trop Dis. 2013 Nov 21;7(11):e2319. doi: 10.1371/journal.pntd.0002319. eCollection 2013 Nov.
2
Epidemiology of endemic systemic fungal infections in Latin America.拉丁美洲地方性系统性真菌感染的流行病学。
Med Mycol. 2011 Nov;49(8):785-98. doi: 10.3109/13693786.2011.577821. Epub 2011 May 4.
3
Development and evaluation of an enzyme-linked immunosorbent assay to detect Histoplasma capsulatum antigenuria in immunocompromised patients.用于检测免疫功能低下患者荚膜组织胞浆菌抗原尿的酶联免疫吸附测定法的开发与评估
Clin Vaccine Immunol. 2009 Jun;16(6):852-8. doi: 10.1128/CVI.00066-09. Epub 2009 Apr 8.
4
Histoplasmosis in HIV-infected patients in a southern regional medical center: poor prognosis in the era of highly active antiretroviral therapy.南方某地区医疗中心HIV感染患者的组织胞浆菌病：高效抗逆转录病毒治疗时代的不良预后
Diagn Microbiol Infect Dis. 2008 Oct;62(2):151-6. doi: 10.1016/j.diagmicrobio.2008.05.006. Epub 2008 Jul 1.
5
Diagnosis of histoplasmosis in immunosuppressed patients.免疫抑制患者组织胞浆菌病的诊断
Curr Opin Infect Dis. 2008 Aug;21(4):421-5. doi: 10.1097/QCO.0b013e328306eb8d.
6
Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group.欧洲癌症研究与治疗组织/侵袭性真菌感染合作组和美国国立过敏与传染病研究所真菌病研究组（EORTC/MSG）共识组对侵袭性真菌病的修订定义。
Clin Infect Dis. 2008 Jun 15;46(12):1813-21. doi: 10.1086/588660.
7
Detection of histoplasma antigen by a quantitative enzyme immunoassay.通过定量酶免疫测定法检测组织胞浆菌抗原。
Clin Vaccine Immunol. 2007 Dec;14(12):1587-91. doi: 10.1128/CVI.00071-07. Epub 2007 Oct 3.
8
Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America.组织胞浆菌病患者管理临床实践指南：美国传染病学会2007年更新版
Clin Infect Dis. 2007 Oct 1;45(7):807-25. doi: 10.1086/521259. Epub 2007 Aug 27.
9
Production and evaluation of reagents for detection of Histoplasma capsulatum antigenuria by enzyme immunoassay.用于通过酶免疫测定法检测荚膜组织胞浆菌抗原尿的试剂的生产与评估。
Clin Vaccine Immunol. 2007 Jun;14(6):700-9. doi: 10.1128/CVI.00083-07. Epub 2007 Apr 11.
10
Elimination of false-positive Histoplasma antigenemia caused by human anti-rabbit antibodies in the second-generation Histoplasma antigen assay.在第二代组织胞浆菌抗原检测中消除由人抗兔抗体引起的假阳性组织胞浆菌抗原血症。
Transpl Infect Dis. 2006 Dec;8(4):219-21. doi: 10.1111/j.1399-3062.2006.00151.x.