一种酶联免疫吸附测定法的验证，该方法用于检测哥伦比亚艾滋病患者尿液中的荚膜组织胞浆菌抗原，以用于诊断及治疗期间的随访。
Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in Colombian patients with AIDS for diagnosis and follow-up during therapy.
作者信息
Caceres Diego H, Scheel Christina M, Tobón Angela M, Ahlquist Cleveland Angela, Restrepo Angela, Brandt Mary E, Chiller Tom, Gómez Beatriz L
机构信息
Corporación para Investigaciones Biológicas (CIB), Medical and Experimental Mycology Group, Medellín, Colombia.
Centers for Disease Control and Prevention, Mycotic Diseases Branch, Atlanta, Georgia, USA.
出版信息
Clin Vaccine Immunol. 2014 Sep;21(9):1364-8. doi: 10.1128/CVI.00101-14. Epub 2014 Jul 9.
Abstract
We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86%, and the overall specificity was 94%. The antigen test successfully monitored the response to therapy.
摘要
我们在患有艾滋病且确诊为组织胞浆菌病的哥伦比亚人中验证了一种抗原捕获酶联免疫吸附测定（ELISA），并评估了随访期间尿抗原与临床改善之间的相关性。荚膜组织胞浆菌ELISA的敏感性为86%，总体特异性为94%。抗原检测成功监测了治疗反应。
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